The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Dynamic Energy Landscape of Dihydrofolate Reductase Catalysis
Abstract
We used nuclear magnetic resonance relaxation dispersion to characterize higher energy conformational substates of Escherichia coli dihydrofolate reductase. Each intermediate in the catalytic cycle samples low-lying excited states whose conformations resemble the ground-state structures of preceding and following intermediates. Substrate and cofactor exchange occurs through these excited substates. The maximum hydride transfer and steady-state turnover rates are governed by the dynamics of transitions between ground and excited states of the intermediates. Thus, the modulation of the energy landscape by the bound ligands funnels the enzyme through its reaction cycle along a preferred kinetic path.
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Cites
Folding funnels, binding funnels, and protein function
Tsai, C., Kumar, S., Ma, B., & Nussinov, R. (1999) · Protein Science · doi:10.1110/ps.8.6.1181 · Cited by 648
Cited by
The role of dynamic conformational ensembles in biomolecular recognition
Boehr, D. D., Nussinov, R., & Wright, P. E. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.232 · Cited by 2,008
Self-citationPutnam, C. D., Hammel, M., Hura, G. L., & Tainer, J. A. (2007) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583507004635 · Cited by 1,184
Conformational selection or induced fit: A flux description of reaction mechanism
Hammes, G. G., Chang, Y.-C., & Oas, T. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907195106 · Cited by 577
An introduction to NMR-based approaches for measuring protein dynamics
Kleckner, I. R., & Foster, M. P. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2010.10.012 · Cited by 561
Serine peptidases: Classification, structure and function
Page, M. J., & Di Cera, E. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7565-9 · Cited by 438
Metadata
- Authors
- Boehr, D. D., McElheny, D., Dyson, H. J., & Wright, P. E.
- Venue
- Science
- Published
- 2006-09-15
- Volume
- 313
- Issue
- 5793
- Pages
- 1638-1642
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083144176
- Cited by
- 957
- References
- 1
- FWCI
- 22.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boehr, D. D., McElheny, D., Dyson, H. J., & Wright, P. E. (2006). The Dynamic Energy Landscape of Dihydrofolate Reductase Catalysis. Science. https://doi.org/10.1126/science.1130258
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
