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Nonequilibrium Mechanics of Active Cytoskeletal Networks
Abstract
Cells both actively generate and sensitively react to forces through their mechanical framework, the cytoskeleton, which is a nonequilibrium composite material including polymers and motor proteins. We measured the dynamics and mechanical properties of a simple three-component model system consisting of myosin II, actin filaments, and cross-linkers. In this system, stresses arising from motor activity controlled the cytoskeletal network mechanics, increasing stiffness by a factor of nearly 100 and qualitatively changing the viscoelastic response of the network in an adenosine triphosphate–dependent manner. We present a quantitative theoretical model connecting the large-scale properties of this active gel to molecular force generation.
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Cites
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Laevsky, G., & Knecht, D. A. (2003) · Journal of Cell Science · doi:10.1242/jcs.00684 · Cited by 120
Cited by
Stochastic thermodynamics, fluctuation theorems and molecular machines
Seifert, U. (2012) · Reports on Progress in Physics · doi:10.1088/0034-4885/75/12/126001 · Cited by 3,300
Liquid-Liquid Phase Separation in Biology
Hyman, A. A., Weber, C. A., & Jülicher, F. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013325 · Cited by 3,155
Mechanotransduction and extracellular matrix homeostasis
Humphrey, J. D., Dufresne, E. R., & Schwartz, M. A. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3896 · Cited by 2,124
Force Generation, Transmission, and Integration during Cell and Tissue Morphogenesis
Lecuit, T., Lenne, P.-F., & Munro, E. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104027 · Cited by 621
Linear and Nonlinear Rheology of Living Cells
Kollmannsberger, P., & Fabry, B. (2011) · Annual Review of Materials Research · doi:10.1146/annurev-matsci-062910-100351 · Cited by 420
Metadata
- Authors
- Mizuno, D., Tardin, C., Schmidt, C. F., & MacKintosh, F. C.
- Venue
- Science
- Published
- 2007-01-19
- Volume
- 315
- Issue
- 5810
- Pages
- 370-373
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059681661
- Cited by
- 951
- References
- 2
- FWCI
- 19.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mizuno, D., Tardin, C., Schmidt, C. F., & MacKintosh, F. C. (2007). Nonequilibrium Mechanics of Active Cytoskeletal Networks. Science. https://doi.org/10.1126/science.1134404
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
