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Immunization by Avian H5 Influenza Hemagglutinin Mutants with Altered Receptor Binding Specificity
Open accessAbstract
Influenza virus entry is mediated by the receptor binding domain (RBD) of its spike, the hemagglutinin (HA). Adaptation of avian viruses to humans is associated with HA specificity for α2,6- rather than α2,3-linked sialic acid (SA) receptors. Here, we define mutations in influenza A subtype H5N1 (avian) HA that alter its specificity for SA either by decreasing α2,3- or increasing α2,6-SA recognition. RBD mutants were used to develop vaccines and monoclonal antibodies that neutralized new variants. Structure-based modification of HA specificity can guide the development of preemptive vaccines and therapeutic monoclonal antibodies that can be evaluated before the emergence of human-adapted H5N1 strains.
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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) · Nature · doi:10.1038/nature02145 · Cited by 5,923
Cited by
Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination
Wei, C.-J., Boyington, J. C., McTamney, P. M., Kong, W.-P., Pearce, M. B., Xu, L., Andersen, H., Rao, S., Tumpey, T. M., Yang, Z.-Y., et al. (2010) · Science · doi:10.1126/science.1192517 · Cited by 337
Self-citationGlycans on influenza hemagglutinin affect receptor binding and immune response
Wang, C.-C., Chen, J.-R., Tseng, Y.-C., Hsu, C.-H., Hung, Y.-F., Chen, S.-W., Chen, C.-M., Khoo, K.-H., Cheng, T.-J., Cheng, Y.-S. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909696106 · Cited by 316
Metadata
- Authors
- Yang, Z.-Y., Wei, C.-J., Kong, W.-P., Wu, L., Xu, L., Smith, D. F., & Nabel, G. J.
- Venue
- Science
- Published
- 2007-08-10
- Volume
- 317
- Issue
- 5839
- Pages
- 825-828
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031908280
- Cited by
- 253
- References
- 1
- FWCI
- 12.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, Z.-Y., Wei, C.-J., Kong, W.-P., Wu, L., Xu, L., Smith, D. F., & Nabel, G. J. (2007). Immunization by Avian H5 Influenza Hemagglutinin Mutants with Altered Receptor Binding Specificity. Science. https://doi.org/10.1126/science.1135165
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