Regulation of γδ Versus αß T Lymphocyte Differentiation by the Transcription Factor SOX13
Abstract
αβ and γδ T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a γδ-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes γδ T cell development while opposing αβ T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of γδ T cells but not αβ T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.
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Expression of Sox13 promotes γδ T cell development while opposing αβ T cell differentiation, and Sox13-deficient mice exhibit impaired γδ T cell development but not αβ T cells.
“Expression of the transcription factor Sox13 promotes γδ T cell development while opposing αβ T cell differentiation. Mice deficient in Sox13 exhibit impaired γδ T cell development but not αβ T cells [11].”
From The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis (2011) · cites this paper as [11]
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The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis
Jabeen, R., Chang, H.-C., Goswami, R., Nutt, S. L., & Kaplan, M. H. (2011) · PLOS ONE · doi:10.1371/journal.pone.0022189 · Cited by 10 · see citing works
- Authors
- Melichar, H. J., Narayan, K., Der, S. D., Hiraoka, Y., Gardiol, N., Jeannet, G., Held, W., Chambers, C. A., & Kang, J.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
- Corresponding author
- Kang, Joonsoo
- Venue
- Science
- Published
- 2007-01-12
- Volume
- 315
- Issue
- 5809
- Pages
- 230-233
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053444110
- Cited by
- 189
- References
- 0
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 11 · 2023: 7 · 2022: 13 · 2021: 8 · 2020: 10 · 2019: 11 · 2018: 7 · 2017: 4 · 2016: 6 · 2015: 9 · 2014: 12 · 2013: 10 · 2012: 8
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@UMassChan (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- National Cancer Institute (R01CA100382, R01CA100382/92614)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- SOX13, γδ T cells, alpha beta T cells, T cell lineage commitment, thymocyte differentiation, Wnt/TCF signaling, transcription factors
- MeSH terms
- Animals, Autoantigens, Cell Line, Gene Expression Regulation, High Mobility Group Proteins, Humans, Mice, Transgenic, Gene Rearrangement, T-Lymphocyte, Signal Transduction, CD4 Antigens, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, gamma-delta, Receptors, Antigen, T-Cell, alpha-beta, Cell Lineage, Gene Expression Profiling, Lymphopoiesis, Embryonic Development, Cell Proliferation, Wnt Proteins, Mice, T Cell Transcription Factor 1
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