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Kinetics of Morphogen Gradient Formation
Abstract
In the developing fly wing, secreted morphogens such as Decapentaplegic (Dpp) and Wingless (Wg) form gradients of concentration providing positional information. Dpp forms a longer-range gradient than Wg. To understand how the range is controlled, we measured the four key kinetic parameters governing morphogen spreading: the production rate, the effective diffusion coefficient, the degradation rate, and the immobile fraction. The four parameters had different values for Dpp versus Wg. In addition, Dynamin-dependent endocytosis was required for spreading of Dpp, but not Wg. Thus, the cellular mechanisms of Dpp and Wingless spreading are different: Dpp spreading requires endocytic, intracellular trafficking.
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Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
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Quantitative diffusion measurements using the open-source software PyFRAP
Bläßle, A., Soh, G., Braun, T., Mörsdorf, D., Preiß, H., Jordan, B. M., & Müller, P. (2018) · Nature Communications · doi:10.1038/s41467-018-03975-6 · Cited by 49
Metadata
- Authors
- Kicheva, A., Pantazis, P., Bollenbach, T., Kalaidzidis, Y., Bittig, T., Jülicher, F., & González-Gaitán, M.
- Venue
- Science
- Published
- 2007-01-26
- Volume
- 315
- Issue
- 5811
- Pages
- 521-525
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965558704
- Cited by
- 397
- References
- 1
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kicheva, A., Pantazis, P., Bollenbach, T., Kalaidzidis, Y., Bittig, T., Jülicher, F., & González-Gaitán, M. (2007). Kinetics of Morphogen Gradient Formation. Science. https://doi.org/10.1126/science.1135774
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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