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Temperature Sex Reversal Implies Sex Gene Dosage in a Reptile
Abstract
Sex in reptiles is determined by genes on sex chromosomes or by incubation temperature. Previously these two modes were thought to be distinct, yet we show that high incubation temperatures reverse genotypic males (ZZ) to phenotypic females in a lizard with ZZ and ZW sex chromosomes. Thus, the W chromosome is not necessary for female differentiation. Sex determination is probably via a dosage-sensitive male-determining gene on the Z chromosome that is inactivated by extreme temperatures. Our data invite a novel hypothesis for the evolution of temperature-dependent sex determination (TSD) and suggest that sex chromosomes may exist in many TSD reptiles.
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Cited by
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species
Nagahama, Y., Chakraborty, T., Paul-Prasanth, B., Ohta, K., & Nakamura, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00044.2019 · Cited by 346
The Genome 10K Project: A Way Forward
Koepfli, K.-P., Paten, B., Scientists, T. G. 1. C. O., & O’Brien, S. J. (2015) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-090414-014900 · Cited by 311
Deveson, I. W., Holleley, C. E., Blackburn, J., Marshall Graves, J. A., Mattick, J. S., Waters, P. D., & Georges, A. (2017) · Science Advances · doi:10.1126/sciadv.1700731 · Cited by 132
“Dragons are exceptional for the fact that genotype (a ZW/ZZ sex chromosome system) interacts with environmental temperature to determine the fate of sexual differentiation (9, 10).”
BackgroundSelf-citation
Metadata
- Authors
- Quinn, A. E., Georges, A., Sarre, S. D., Guarino, F., Ezaz, T., & Graves, J. A. M.
- Venue
- Science
- Published
- 2007-04-20
- Volume
- 316
- Issue
- 5823
- Pages
- 411-411
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2118429564
- Cited by
- 274
- References
- 0
- FWCI
- 10.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Quinn, A. E., Georges, A., Sarre, S. D., Guarino, F., Ezaz, T., & Graves, J. A. M. (2007). Temperature Sex Reversal Implies Sex Gene Dosage in a Reptile. Science. https://doi.org/10.1126/science.1135925
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