Nuclear Activity of MLA Immune Receptors Links Isolate-Specific and Basal Disease-Resistance Responses
Open accessAbstract
Plant immune responses are triggered by pattern recognition receptors that detect conserved pathogen-associated molecular patterns (PAMPs) or by resistance (R) proteins recognizing isolate-specific pathogen effectors. We show that in barley, intracellular mildew A (MLA) R proteins function in the nucleus to confer resistance against the powdery mildew fungus. Recognition of the fungal avirulence A10 effector by MLA10 induces nuclear associations between receptor and WRKY transcription factors. The identified WRKY proteins act as repressors of PAMP-triggered basal defense. MLA appears to interfere with the WRKY repressor function, thereby de-repressing PAMP-triggered basal defense. Our findings reveal a mechanism by which these polymorphic immune receptors integrate distinct pathogen signals.
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TIR-like proteins, among which are Toll receptors, are major regulators of phagocytosis and pathogen-response in animals.
“TIR-like proteins, among which are Toll receptors, are major regulators of phagocytosis and pathogen-response in animals [54,66-68].”
From Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium (2008) · cites this paper as [54]
WKRY transcription factors have been shown to be positive and negative regulators of pathogen defense pathways in plants.
“WKRY transcription factors, in particular, have been shown to be positive and negative regulators of pathogen defense pathways in plants [54].”
From Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium (2008) · cites this paper as [54]
Intracellular effectors with TIR-like domains have been recently shown to enter the nucleus and to regulate immune-like response in plants, acting on WRKY transcription factors, which negatively regulate such response.
“Interestingly, intracellular effectors with TIR-like domains have been recently shown to enter the nucleus and to regulate immune-like response in plants, acting on WRKY transcription factors, which negatively regulate such response [54,66,68].”
From Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium (2008) · cites this paper as [54]
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Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium
Sillo, A., Bloomfield, G., Balest, A., Balbo, A., Pergolizzi, B., Peracino, B., Skelton, J., Ivens, A., & Bozzaro, S. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-291 · Cited by 69 · see citing works
- Authors
- Shen, Q.-H., Saijo, Y., Mauch, S., Biskup, C., Bieri, S., Keller, B., Seki, H., Ülker, B., Somssich, I. E., & Schulze-Lefert, P.
- Affiliations
- Max Planck Society (DE)
- Department of Plant Microbe Interactions, Max-Planck-Institut für Züchtungsforschung, Carl-von-Linné-Weg 10, D-50829 Köln, Germany.
- Corresponding author
- Seki, Hikaru
- Venue
- Science
- Published
- 2007-02-23
- Volume
- 315
- Issue
- 5815
- Pages
- 1098-1103
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083300694
- Cited by
- 751
- References
- 0
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 25 · 2023: 19 · 2022: 33 · 2021: 43 · 2020: 30 · 2019: 26 · 2018: 29 · 2017: 28 · 2016: 46 · 2015: 33 · 2014: 40 · 2013: 59 · 2012: 48
- FWCI
- 65.63
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Powdery Mildew Fungal Diseases
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Disease Resistance and Genetics
- Keywords
- barley, powdery mildew, WRKY transcription factors, nuclear receptor localization, basal defense, pattern-triggered immunity, isolate-specific resistance, disease resistance
- MeSH terms
- Amino Acid Sequence, Ascomycota, Hordeum, Cell Nucleus, Cytoplasm, Fungal Proteins, Immunity, Innate, Molecular Sequence Data, Mutation, Plant Diseases, Plant Proteins, Receptors, Immunologic, Recombinant Fusion Proteins, Transcription Factors, Arabidopsis, Protein Structure, Tertiary, Two-Hybrid System Techniques, Arabidopsis Proteins, Plants, Genetically Modified, Receptors, Pattern Recognition
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