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Signals from Chloroplasts Converge to Regulate Nuclear Gene Expression
Abstract
Plastid-to-nucleus retrograde signaling coordinates nuclear gene expression with chloroplast function and is essential for the photoautotrophic life-style of plants. Three retrograde signals have been described, but little is known of their signaling pathways. We show here that GUN1, a chloroplast-localized pentatricopeptide-repeat protein, and ABI4, an Apetala 2 (AP2)–type transcription factor, are common to all three pathways. ABI4 binds the promoter of a retrograde-regulated gene through a conserved motif found in close proximity to a light-regulatory element. We propose a model in which multiple indicators of aberrant plastid function in Arabidopsis are integrated upstream of GUN1 within plastids, which leads to ABI4-mediated repression of nuclear-encoded genes.
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Metadata
- Authors
- Koussevitzky, S., Nott, A., Mockler, T. C., Hong, F., Sachetto-Martins, G., Surpin, M., Lim, J., Mittler, R., & Chory, J.
- Venue
- Science
- Published
- 2007-05-04
- Volume
- 316
- Issue
- 5825
- Pages
- 715-719
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4292690773
- Cited by
- 400
- References
- 0
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Koussevitzky, S., Nott, A., Mockler, T. C., Hong, F., Sachetto-Martins, G., Surpin, M., Lim, J., Mittler, R., & Chory, J. (2007). Signals from Chloroplasts Converge to Regulate Nuclear Gene Expression. Science. https://doi.org/10.1126/science.1140516
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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