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Genes Required for Mitotic Spindle Assembly in Drosophila S2 Cells
Open accessAbstract
The formation of a metaphase spindle, a bipolar microtubule array with centrally aligned chromosomes, is a prerequisite for the faithful segregation of a cell's genetic material. Using a full-genome RNA interference screen of Drosophila S2 cells, we identified about 200 genes that contribute to spindle assembly, more than half of which were unexpected. The screen, in combination with a variety of secondary assays, led to new insights into how spindle microtubules are generated; how centrosomes are positioned; and how centrioles, centrosomes, and kinetochores are assembled.
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Cited by
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Cheeseman, I. M., & Desai, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2310 · Cited by 915
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Guo, Y., Walther, T. C., Rao, M., Stuurman, N., Goshima, G., Terayama, K., Wong, J. S., Vale, R. D., Walter, P., & Farese, R. V. (2008) · Nature · doi:10.1038/nature06928 · Cited by 719
Self-citationVerhey, K. J., & Gaertig, J. (2007) · Cell Cycle · doi:10.4161/cc.6.17.4633 · Cited by 558
Systematic Analysis of Human Protein Complexes Identifies Chromosome Segregation Proteins
Hutchins, J. R. A., Toyoda, Y., Hegemann, B., Poser, I., Hériché, J.-K., Sykora, M. M., Augsburg, M., Hudecz, O., Buschhorn, B. A., Bulkescher, J., et al. (2010) · Science · doi:10.1126/science.1181348 · Cited by 502
Label-free prediction of three-dimensional fluorescence images from transmitted-light microscopy
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Metadata
- Authors
- Goshima, G., Wollman, R., Goodwin, S. S., Zhang, N., Scholey, J. M., Vale, R. D., & Stuurman, N.
- Venue
- Science
- Published
- 2007-04-20
- Volume
- 316
- Issue
- 5823
- Pages
- 417-421
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2033797646
- Cited by
- 525
- References
- 0
- FWCI
- 17.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Goshima, G., Wollman, R., Goodwin, S. S., Zhang, N., Scholey, J. M., Vale, R. D., & Stuurman, N. (2007). Genes Required for Mitotic Spindle Assembly in Drosophila S2 Cells. Science. https://doi.org/10.1126/science.1141314
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