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Revisiting the Role of the Mother Centriole in Centriole Biogenesis
Open accessAbstract
Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4 (SAK/PLK4), a kinase implicated in tumor development, is an upstream regulator of canonical biogenesis necessary for centriole formation. We found that overexpression of SAK/PLK4 could induce amplification of centrioles in Drosophila embryos and their de novo formation in unfertilized eggs. Both processes required the activity of DSAS-6 and DSAS-4, two molecules required for canonical duplication. Thus, centriole biogenesis is a template-free self-assembly process triggered and regulated by molecules that ordinarily associate with the existing centriole. The mother centriole is not a bona fide template but a platform for a set of regulatory molecules that catalyzes and regulates daughter centriole assembly.
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Cited by
Primary Cilia and the Cell Cycle
Plotnikova, O. V., Pugacheva, E. N., & Golemis, E. A. (2009) · Methods in Cell Biology · doi:10.1016/s0091-679x(08)94007-3 · Cited by 236
Ohta, M., Ashikawa, T., Nozaki, Y., Kozuka-Hata, H., Goto, H., Inagaki, M., Oyama, M., & Kitagawa, D. (2014) · Nature Communications · doi:10.1038/ncomms6267 · Cited by 238
Frank, C. L., & Tsai, L.-H. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.029 · Cited by 118
Metadata
- Authors
- Rodrigues-Martins, A., Riparbelli, M., Callaini, G., Glover, D. M., & Bettencourt-Dias, M.
- Venue
- Science
- Published
- 2007-05-18
- Volume
- 316
- Issue
- 5827
- Pages
- 1046-1050
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2078073456
- Cited by
- 245
- References
- 0
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Rodrigues-Martins, A., Riparbelli, M., Callaini, G., Glover, D. M., & Bettencourt-Dias, M. (2007). Revisiting the Role of the Mother Centriole in Centriole Biogenesis. Science. https://doi.org/10.1126/science.1142950
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