The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Stabilizing Isopeptide Bonds Revealed in Gram-Positive Bacterial Pilus Structure
Open accessAbstract
Many bacterial pathogens have long, slender pili through which they adhere to host cells. The crystal structure of the major pilin subunit from the Gram-positive human pathogen Streptococcus pyogenes at 2.2 angstroms resolution reveals an extended structure comprising two all-β domains. The molecules associate in columns through the crystal, with each carboxyl terminus adjacent to a conserved lysine of the next molecule. This lysine forms the isopeptide bonds that link the subunits in native pili, validating the relevance of the crystal assembly. Each subunit contains two lysine-asparagine isopeptide bonds generated by an intramolecular reaction, and we find evidence for similar isopeptide bonds in other cell surface proteins of Gram-positive bacteria. The present structure explains the strength and stability of such Gram-positive pili and could facilitate vaccine development.
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Cites
Assembly of pili on the surface of Corynebacterium diphtheriae
Ton‐That, H., & Schneewind, O. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03782.x · Cited by 354
Protein sorting to the cell wall envelope of Gram-positive bacteria
Ton-That, H., Marraffini, L. A., & Schneewind, O. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.04.014 · Cited by 266
Cited by
Kankainen, M., Paulin, L., Tynkkynen, S., von Ossowski, I., Reunanen, J., Partanen, P., Satokari, R., Vesterlund, S., Hendrickx, A. P. A., Lebeer, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908876106 · Cited by 740
Streptococcus Adherence and Colonization
Nobbs, A. H., Lamont, R. J., & Jenkinson, H. F. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00014-09 · Cited by 657
Stick to Your Gums: Mechanisms of Oral Microbial Adherence
Nobbs, A. H., Jenkinson, H. F., & Jakubovics, N. S. (2011) · Journal of Dental Research · doi:10.1177/0022034511399096 · Cited by 139
Oxaran, V., Ledue-Clier, F., Dieye, Y., Herry, J.-M., Péchoux, C., Meylheuc, T., Briandet, R., Juillard, V., & Piard, J.-C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050989 · Cited by 73
Metadata
- Authors
- Kang, H. J., Coulibaly, F., Clow, F., Proft, T., & Baker, E. N.
- Venue
- Science
- Published
- 2007-12-07
- Volume
- 318
- Issue
- 5856
- Pages
- 1625-1628
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2056680298
- Cited by
- 345
- References
- 2
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Kang, H. J., Coulibaly, F., Clow, F., Proft, T., & Baker, E. N. (2007). Stabilizing Isopeptide Bonds Revealed in Gram-Positive Bacterial Pilus Structure. Science. https://doi.org/10.1126/science.1145806
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