The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Disentangling Genetic Variation for Resistance and Tolerance to Infectious Diseases in Animals
Open accessAbstract
Hosts can in principle employ two different strategies to defend themselves against parasites: resistance and tolerance. Animals typically exhibit considerable genetic variation for resistance (the ability to limit parasite burden). However, little is known about whether animals can evolve tolerance (the ability to limit the damage caused by a given parasite burden). Using rodent malaria in laboratory mice as a model system and the statistical framework developed by plant-pathogen biologists, we demonstrated genetic variation for tolerance, as measured by the extent to which anemia and weight loss increased with increasing parasite burden. Moreover, resistance and tolerance were negatively genetically correlated. These results mean that animals, like plants, can evolve two conceptually different types of defense, a finding that has important implications for the understanding of the epidemiology and evolution of infectious diseases.
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Citations
Cites
Experimental Design and Data Analysis for Biologists
Quinn, G. P., & Keough, M. J. (2002) · doi:10.1017/cbo9780511806384 · Cited by 10,674 · cited 2×
“Thus, resistance and tolerance have contrasting effects on the epidemiology of infectious diseases (5, 7).”
Background
Cited by
Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005
Disease Tolerance as a Defense Strategy
Medzhitov, R., Schneider, D. S., & Soares, M. P. (2012) · Science · doi:10.1126/science.1214935 · Cited by 1,718
Schneider, D. S., & Ayres, J. S. (2008) · Nature Reviews Immunology · doi:10.1038/nri2432 · Cited by 783
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation
Wang, A., Huen, S. C., Luan, H. H., Yu, S., Zhang, C., Gallezot, J.-D., Booth, C. J., & Medzhitov, R. (2016) · Cell · doi:10.1016/j.cell.2016.07.026 · Cited by 579
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance
Luan, H. H., Wang, A., Hilliard, B. K., Carvalho, F., Rosen, C. E., Ahasic, A. M., Herzog, E. L., Kang, I., Pisani, M. A., Yu, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.033 · Cited by 527
Metadata
- Authors
- Råberg, L., Sim, D., & Read, A. F.
- Venue
- Science
- Published
- 2007-11-02
- Volume
- 318
- Issue
- 5851
- Pages
- 812-814
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2063838707
- Cited by
- 794
- References
- 1
- FWCI
- 13.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Råberg, L., Sim, D., & Read, A. F. (2007). Disentangling Genetic Variation for Resistance and Tolerance to Infectious Diseases in Animals. Science. https://doi.org/10.1126/science.1148526
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
