The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A Polymorphism Within the G6PC2 Gene Is Associated with Fasting Plasma Glucose Levels
Open accessAbstract
Several studies have shown that healthy individuals with fasting plasma glucose (FPG) levels at the high end of the normal range have an increased risk of mortality. To identify genetic determinants that contribute to interindividual variation in FPG, we tested 392,935 single-nucleotide polymorphisms (SNPs) in 654 normoglycemic participants for association with FPG, and we replicated the most strongly associated SNP (rs560887, P = 4 × 10 –7 ) in 9353 participants. SNP rs560887 maps to intron 3 of the G6PC2 gene, which encodes glucose-6-phosphatase catalytic subunit–related protein (also known as IGRP), a protein selectively expressed in pancreatic islets. This SNP was associated with FPG (linear regression coefficient β = –0.06 millimoles per liter per A allele, combined P = 4 × 10 –23 ) and with pancreatic β cell function (Homa-B model, combined P = 3 × 10 –13 ) in three populations; however, it was not associated with type 2 diabetes risk. We speculate that G6PC2 regulates FPG by modulating the set point for glucose-stimulated insulin secretion in pancreatic β cells.
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A genome-wide association study identifies novel risk loci for type 2 diabetes
Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., et al. (2007) · Nature · doi:10.1038/nature05616 · Cited by 2,993
Self-citationGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753
Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194
The DECODE Study Group, & on behalf of the European Diabetes Epidemiology Group (2003) · Diabetes Care · doi:10.2337/diacare.26.3.688 · Cited by 516
Cited by
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
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Self-citationInsulin and insulin-like growth factor signalling in neoplasia
Pollak, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2536 · Cited by 2,059
Variants in MTNR1B influence fasting glucose levels
Prokopenko, I., Langenberg, C., Florez, J. C., Saxena, R., Soranzo, N., Thorleifsson, G., Loos, R. J. F., Manning, A. K., Jackson, A. U., Aulchenko, Y., et al. (2009) · Nature Genetics · doi:10.1038/ng.290 · Cited by 744
Self-citationCommon disorders are quantitative traits
Plomin, R., Haworth, C. M. A., & Davis, O. S. P. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2670 · Cited by 670
Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., Delplanque, J., Lobbens, S., Rocheleau, G., Durand, E., et al. (2009) · Nature Genetics · doi:10.1038/ng.277 · Cited by 611
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Metadata
- Authors
- Bouatia-Naji, N., Rocheleau, G., Van Lommel, L., Lemaire, K., Schuit, F., Cavalcanti-Proença, C., Marchand, M., Hartikainen, A.-L., Sovio, U., De Graeve, F., Rung, J., Vaxillaire, M., Tichet, J., Marre, M., Balkau, B., Weill, J., Elliott, P., Jarvelin, M.-R., Meyre, D., Polychronakos, C., Dina, C., Sladek, R., & Froguel, P.
- Venue
- Science
- Published
- 2008-05-23
- Volume
- 320
- Issue
- 5879
- Pages
- 1085-1088
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2096880956
- Cited by
- 243
- References
- 5
- FWCI
- 18.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Bouatia-Naji, N., Rocheleau, G., Van Lommel, L., Lemaire, K., Schuit, F., Cavalcanti-Proença, C., Marchand, M., Hartikainen, A.-L., Sovio, U., De Graeve, F., Rung, J., Vaxillaire, M., Tichet, J., Marre, M., Balkau, B., Weill, J., Elliott, P., Jarvelin, M.-R., Meyre, D., . . . Froguel, P. (2008). A Polymorphism Within the G6PC2 Gene Is Associated with Fasting Plasma Glucose Levels. Science. https://doi.org/10.1126/science.1156849
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