The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Remeasuring the Double Helix
Open accessAbstract
DNA is thought to behave as a stiff elastic rod with respect to the ubiquitous mechanical deformations inherent to its biology. To test this model at short DNA lengths, we measured the mean and variance of end-to-end length for a series of DNA double helices in solution, using small-angle x-ray scattering interference between gold nanocrystal labels. In the absence of applied tension, DNA is at least one order of magnitude softer than measured by single-molecule stretching experiments. Further, the data rule out the conventional elastic rod model. The variance in end-to-end length follows a quadratic dependence on the number of base pairs rather than the expected linear dependence, indicating that DNA stretching is cooperative over more than two turns of the DNA double helix. Our observations support the idea of long-range allosteric communication through DNA structure.
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Cites
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
WATSON, J. D., & CRICK, F. H. C. (1953) · Nature · doi:10.1038/171737a0 · Cited by 13,584
Cited by
Multilayer DNA Origami Packed on a Square Lattice
Ke, Y., Douglas, S. M., Liu, M., Sharma, J., Cheng, A., Leung, A., Liu, Y., Shih, W. M., & Yan, H. (2009) · Journal of the American Chemical Society · doi:10.1021/ja906381y · Cited by 414
Extreme Bendability of DNA Less than 100 Base Pairs Long Revealed by Single-Molecule Cyclization
Vafabakhsh, R., & Ha, T. (2012) · Science · doi:10.1126/science.1224139 · Cited by 301
RNA intrusions change DNA elastic properties and structure
Chiu, H.-C., Koh, K. D., Evich, M., Lesiak, A. L., Germann, M. W., Bongiorno, A., Riedo, E., & Storici, F. (2014) · Nanoscale · doi:10.1039/c4nr01794c · Cited by 56
Shi, X., Herschlag, D., & Harbury, P. A. B. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218830110 · Cited by 41
Self-citationFrom a structural average to the conformational ensemble of a DNA bulge
Shi, X., Beauchamp, K. A., Harbury, P. B., & Herschlag, D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317032111 · Cited by 38
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Metadata
- Authors
- Mathew-Fenn, R. S., Das, R., & Harbury, P. A. B.
- Venue
- Science
- Published
- 2008-10-17
- Volume
- 322
- Issue
- 5900
- Pages
- 446-449
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2157650085
- Cited by
- 218
- References
- 1
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
