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Wolbachia and Virus Protection in Insects
Abstract
Wolbachia pipientis bacteria are common endosymbionts of insects that are best known for their ability to increase their prevalence in populations by manipulating host reproductive systems. However, there are examples of Wolbachia that exist in nature that seem to induce no reproductive parasitism trait and yet are able to invade populations. We demonstrate a fitness benefit for Wolbachia-infected insects that may explain this paradox. Drosophila melanogaster flies infected with Wolbachia are less susceptible to mortality induced by a range of RNA viruses. The antiviral protection associated with Wolbachia infection might be exploited in future strategies to reduce transmission of pathogens by insects.
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Citations
Cited by
Consequences of the Expanding Global Distribution of Aedes albopictus for Dengue Virus Transmission
Lambrechts, L., Scott, T. W., & Gubler, D. J. (2010) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0000646 · Cited by 788
The Ecology and Evolution of Microbes that Manipulate Host Reproduction
Engelstädter, J., & Hurst, G. D. D. (2009) · Annual Review of Ecology, Evolution, and Systematics · doi:10.1146/annurev.ecolsys.110308.120206 · Cited by 555
Biological Control of Mosquito Vectors: Past, Present, and Future
Benelli, G., Jeffries, C., & Walker, T. (2016) · Insects · doi:10.3390/insects7040052 · Cited by 445
Beyond insecticides: new thinking on an ancient problem
McGraw, E. A., & O'Neill, S. L. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2968 · Cited by 381
Self-citationDisease tolerance and immunity in host protection against infection
Soares, M. P., Teixeira, L., & Moita, L. F. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2016.136 · Cited by 376
Metadata
- Authors
- Hedges, L. M., Brownlie, J. C., O'Neill, S. L., & Johnson, K. N.
- Venue
- Science
- Published
- 2008-10-31
- Volume
- 322
- Issue
- 5902
- Pages
- 702-702
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2075519966
- Cited by
- 1,107
- References
- 0
- FWCI
- 67.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hedges, L. M., Brownlie, J. C., O'Neill, S. L., & Johnson, K. N. (2008). Wolbachia and Virus Protection in Insects. Science. https://doi.org/10.1126/science.1162418
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.