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A Genetic Framework for the Control of Cell Division and Differentiation in the Root Meristem
Abstract
Plant growth and development are sustained by meristems. Meristem activity is controlled by auxin and cytokinin, two hormones whose interactions in determining a specific developmental output are still poorly understood. By means of a comprehensive genetic and molecular analysis in Arabidopsis , we show that a primary cytokinin-response transcription factor, ARR1, activates the gene SHY2/IAA3 ( SHY2 ), a repressor of auxin signaling that negatively regulates the PIN auxin transport facilitator genes: thereby, cytokinin causes auxin redistribution, prompting cell differentiation. Conversely, auxin mediates degradation of the SHY2 protein, sustaining PIN activities and cell division. Thus, the cell differentiation and division balance necessary for controlling root meristem size and root growth is the result of the interaction between cytokinin and auxin through a simple regulatory circuit converging on the SHY2 gene.
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Cited by
The roots of a new green revolution
Herder, G. D., Van Isterdael, G., Beeckman, T., & De Smet, I. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.08.009 · Cited by 508
SCFTIR1/AFB-Based Auxin Perception: Mechanism and Role in Plant Growth and Development
Salehin, M., Bagchi, R., & Estelle, M. (2015) · The Plant Cell · doi:10.1105/tpc.114.133744 · Cited by 462
da Costa, C. T., de Almeida, M. R., Ruedell, C. M., Schwambach, J., Maraschin, F. S., & Fett-Neto, A. G. (2013) · Frontiers in Plant Science · doi:10.3389/fpls.2013.00133 · Cited by 417
Moubayidin, L., Di Mambro, R., & Sabatini, S. (2009) · Trends in Plant Science · doi:10.1016/j.tplants.2009.06.010 · Cited by 375
Self-citationSalehin, M., Li, B., Tang, M., Katz, E., Song, L., Ecker, J. R., Kliebenstein, D. J., & Estelle, M. (2019) · Nature Communications · doi:10.1038/s41467-019-12002-1 · Cited by 311
Metadata
- Authors
- Ioio, R. D., Nakamura, K., Moubayidin, L., Perilli, S., Taniguchi, M., Morita, M. T., Aoyama, T., Costantino, P., & Sabatini, S.
- Venue
- Science
- Published
- 2008-11-28
- Volume
- 322
- Issue
- 5906
- Pages
- 1380-1384
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2118867617
- Cited by
- 944
- References
- 0
- FWCI
- 51.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ioio, R. D., Nakamura, K., Moubayidin, L., Perilli, S., Taniguchi, M., Morita, M. T., Aoyama, T., Costantino, P., & Sabatini, S. (2008). A Genetic Framework for the Control of Cell Division and Differentiation in the Root Meristem. Science. https://doi.org/10.1126/science.1164147
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