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Cited by 1,098Plant-Microbe Interactions and ImmunityInsect-Plant Interactions and ControlImmune Response and Inflammation

Glucosinolate Metabolites Required for an Arabidopsis Innate Immune Response

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Clay, Nicole K., Adio, Adewale M., Denoux, Carine, Jander, Georg, Ausubel, Frederick M.·2009·Science
DOI 10.1126/science.1164627PMC PMC2630859
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Abstract

The perception of pathogen or microbe-associated molecular pattern molecules by plants triggers a basal defense response analogous to animal innate immunity and is defined partly by the deposition of the glucan polymer callose at the cell wall at the site of pathogen contact. Transcriptional and metabolic profiling in Arabidopsis mutants, coupled with the monitoring of pathogen-triggered callose deposition, have identified major roles in pathogen response for the plant hormone ethylene and the secondary metabolite 4-methoxy-indol-3-ylmethylglucosinolate. Two genes, PEN2 and PEN3 , are also necessary for resistance to pathogens and are required for both callose deposition and glucosinolate activation, suggesting that the pathogen-triggered callose response is required for resistance to microbial pathogens. Our study shows that well-studied plant metabolites, previously identified as important in avoiding damage by herbivores, are also required as a component of the plant defense response against microbial pathogens.

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Authors
Clay, N. K., Adio, A. M., Denoux, C., Jander, G., & Ausubel, F. M.
Affiliations
Harvard University (US)
Corresponding author
Ausubel, Frederick M.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2009-01-02
Volume
323
Issue
5910
Pages
95-101
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1164627
PMC
PMC2630859
OpenAlex
W1995828353
Cited by
1,098
References
0
Citations by year
2026: 26 · 2025: 33 · 2024: 49 · 2023: 65 · 2022: 84 · 2021: 66 · 2020: 76 · 2019: 71 · 2018: 56 · 2017: 75 · 2016: 68 · 2015: 62 · 2014: 73 · 2013: 67 · 2012: 57
FWCI
68.31
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of General Medical Sciences (R37 GM48707, R37GM048707)
  • National Institute of Allergy and Infectious Diseases (F32AI066817)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
glucosinolates, plant innate immunity, callose deposition, Arabidopsis thaliana, ethylene, Pen-2, PEN3, pathogen resistance, plant defense signaling
MeSH terms
Ethylenes, Flagellin, Glucans, Glucosinolates, Glycoside Hydrolases, Hydrolysis, Immunity, Innate, Indoles, Mutation, N-Glycosyl Hydrolases, Peptide Fragments, Transcription Factors, Signal Transduction, Genes, Plant, Arabidopsis, Gene Expression Regulation, Plant, ATP-Binding Cassette Transporters, Aminoacyltransferases, Salicylic Acid, Arabidopsis Proteins

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