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Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome
Open accessAbstract
The termination of protein synthesis occurs through the specific recognition of a stop codon in the A site of the ribosome by a release factor (RF), which then catalyzes the hydrolysis of the nascent protein chain from the P-site transfer RNA. Here we present, at a resolution of 3.5 angstroms, the crystal structure of RF2 in complex with its cognate UGA stop codon in the 70 S ribosome. The structure provides insight into how RF2 specifically recognizes the stop codon; it also suggests a model for the role of a universally conserved GGQ motif in the catalysis of peptide release.
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Cited by
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Metadata
- Authors
- Weixlbaumer, A., Jin, H., Neubauer, C., Voorhees, R. M., Petry, S., Kelley, A. C., & Ramakrishnan, V.
- Venue
- Science
- Published
- 2008-11-07
- Volume
- 322
- Issue
- 5903
- Pages
- 953-956
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989067983
- Cited by
- 308
- References
- 0
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Weixlbaumer, A., Jin, H., Neubauer, C., Voorhees, R. M., Petry, S., Kelley, A. C., & Ramakrishnan, V. (2008). Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome. Science. https://doi.org/10.1126/science.1164840
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