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Dynamical Quorum Sensing and Synchronization in Large Populations of Chemical Oscillators
Abstract
Populations of certain unicellular organisms, such as suspensions of yeast in nutrient solutions, undergo transitions to coordinated activity with increasing cell density. The collective behavior is believed to arise through communication by chemical signaling via the extracellular solution. We studied large, heterogeneous populations of discrete chemical oscillators (∼100,000) with well-defined kinetics to characterize two different types of density-dependent transitions to synchronized oscillatory behavior. For different chemical exchange rates between the oscillators and the surrounding solution, increasing oscillator density led to (i) the gradual synchronization of oscillatory activity, or (ii) the sudden “switching on” of synchronized oscillatory activity. We analyze the roles of oscillator density and exchange rate of signaling species in these transitions with a mathematical model of the interacting chemical oscillators.
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Cited by
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Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 533
Quorum sensing and social networking in the microbial world
Atkinson, S., & Williams, P. (2009) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0203 · Cited by 422
Rational design of functional and tunable oscillating enzymatic networks
Semenov, S. N., Wong, A. S. Y., van der Made, R. M., Postma, S. G. J., Groen, J., van Roekel, H. W. H., de Greef, T. F. A., & Huck, W. T. S. (2015) · Nature Chemistry · doi:10.1038/nchem.2142 · Cited by 285
Reaction–diffusion processes at the nano- and microscales
Epstein, I. R., & Xu, B. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.41 · Cited by 284
Metadata
- Authors
- Taylor, A. F., Tinsley, M. R., Wang, F., Huang, Z., & Showalter, K.
- Venue
- Science
- Published
- 2009-01-30
- Volume
- 323
- Issue
- 5914
- Pages
- 614-617
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963493422
- Cited by
- 424
- References
- 0
- FWCI
- 39.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taylor, A. F., Tinsley, M. R., Wang, F., Huang, Z., & Showalter, K. (2009). Dynamical Quorum Sensing and Synchronization in Large Populations of Chemical Oscillators. Science. https://doi.org/10.1126/science.1166253
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