The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors
Abstract
Sphingosine-1-phosphate (S1P) is a secreted lipid mediator that functions in vascular development; however, it remains unclear how S1P secretion is regulated during embryogenesis. We identified a zebrafish mutant, ko157 , that displays cardia bifida (two hearts) resembling that in the S1P receptor-2 mutant. A migration defect of myocardial precursors in the ko157 mutant is due to a mutation in a multipass transmembrane protein, Spns2, and can be rescued by S1P injection. We show that the export of S1P from cells requires Spns2. spns2 is expressed in the extraembryonic tissue yolk syncytial layer (YSL), and the introduction of spns2 mRNA in the YSL restored the cardiac defect in the ko157 mutant. Thus, Spns2 in the YSL functions as a S1P transporter in S1P secretion, thereby regulating myocardial precursor migration.
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Cites
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667
Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene
Montosi, G., Donovan, A., Totaro, A., Garuti, C., Pignatti, E., Cassanelli, S., Trenor, C. C., Gasparini, P., Andrews, N. C., & Pietrangelo, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113468 · Cited by 557
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells
Mitra, P., Oskeritzian, C. A., Payne, S. G., Beaven, M. A., Milstien, S., & Spiegel, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603734103 · Cited by 407
Cited by
Sphingosine-1-phosphate signaling and its role in disease
Maceyka, M., Harikumar, K. B., Milstien, S., & Spiegel, S. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.09.003 · Cited by 1,039
The outs and the ins of sphingosine-1-phosphate in immunity
Spiegel, S., & Milstien, S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2974 · Cited by 810
An update on the biology of sphingosine 1-phosphate receptors
Blaho, V. A., & Hla, T. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046300 · Cited by 516
Pham, T. H. M., Baluk, P., Xu, Y., Grigorova, I., Bankovich, A. J., Pappu, R., Coughlin, S. R., McDonald, D. M., Schwab, S. R., & Cyster, J. G. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091619 · Cited by 444
An update on sphingosine-1-phosphate and other sphingolipid mediators
Fyrst, H., & Saba, J. D. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.392 · Cited by 344
Metadata
- Authors
- Kawahara, A., Nishi, T., Hisano, Y., Fukui, H., Yamaguchi, A., & Mochizuki, N.
- Venue
- Science
- Published
- 2009-01-23
- Volume
- 323
- Issue
- 5913
- Pages
- 524-527
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070677984
- Cited by
- 405
- References
- 3
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kawahara, A., Nishi, T., Hisano, Y., Fukui, H., Yamaguchi, A., & Mochizuki, N. (2009). The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors. Science. https://doi.org/10.1126/science.1167449
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