The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Unstable Tandem Repeats in Promoters Confer Transcriptional Evolvability
Open accessAbstract
Genotype, Phenotype, and Variation: Phenotypic evolution results from changes in coding sequences, as well as in regulatory regions of the genome. Vinces et al. (p. 1213 ) uncover an abundant source of gene expression variability in the promoters of Saccharomyces cerevisiae genes. Up to 25% of yeast promoter regions contain a highly variable tandem repeat sequence, which effect gene expression and local chromatin structure. The intrinsic instability of these repeats generates variability in gene expression levels and provides a mechanism for rapid evolution of phenotypic traits.
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Cites
A genome-wide view of the spectrum of spontaneous mutations in yeast.
Lynch, M., Sung, W., Morris, K., Coffey, N., Landry, C. R., Dopman, E. B., Dickinson, W. J., Okamoto, K., Kulkarni, S., Hartl, D. L., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803466105 · Cited by 708
Cited by
Variable tandem repeats accelerate evolution of coding and regulatory sequences
Gemayel, R., Vinces, M. D., Legendre, M., & Verstrepen, K. J. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-072610-155046 · Cited by 633
Self-citationComparative studies of gene expression and the evolution of gene regulation
Romero, I. G., Ruvinsky, I., & Gilad, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3229 · Cited by 488
Abundant contribution of short tandem repeats to gene expression variation in humans
Gymrek, M., Willems, T., Guilmatre, A., Zeng, H., Markus, B., Georgiev, S., Daly, M. J., Price, A. L., Pritchard, J. K., Sharp, A. J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3461 · Cited by 410
Annotating non-coding regions of the genome.
Alexander, R. P., Fang, G., Rozowsky, J., Snyder, M., & Gerstein, M. B. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2814 · Cited by 464
Metadata
- Authors
- Vinces, M. D., Legendre, M., Caldara, M., Hagihara, M., & Verstrepen, K. J.
- Venue
- Science
- Published
- 2009-05-29
- Volume
- 324
- Issue
- 5931
- Pages
- 1213-1216
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043257091
- Cited by
- 370
- References
- 1
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- green
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