Recruitment of Antigen-Specific CD8 + T Cells in Response to Infection Is Markedly Efficient
Open accessAbstract
Preparation for Cell Wars: When T cells encounter an infection, they proliferate to create a larger army to fight the invader. The overall magnitude of the T cell response depends on the severity of infection and is determined by the number of T cells of a particular antigen specificity that are initially recruited, as well as the magnitude of the proliferative response. The extent to which these two components contribute to the response is unknown. By using DNA barcoding to track the responses of individual T cells, van Heijst et al. (p. 1265 ) showed that the recruitment of T cells of a particular antigen specificity is similar and nearly complete, but that the extent of the proliferative response differed, and this determined the overall magnitude of the T cell response.
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Increased clonal sizes are a hallmark of immune memory, and clonal dominance is normal for memory T cell responses to a single peptide, likely due to antigen-driven selection.
“Increase in clonal sizes is a hallmark of immune memory; moreover, clonal dominance is quite normal for the memory T cell repertoire responding to a single peptide”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as van Heijst et al., 2009
In mice, the TCR repertoire to an antigenic peptide follows a power law distribution with many specificities and only a few gaining dominance.
“In mice, the TCR repertoire to an antigenic peptide follows a power law distribution involving a large number of T cell specificities, with only a few of them gaining dominance”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as van Heijst et al., 2009
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References 16 · Cited by 146
- Authors
- van Heijst, J. W. J., Gerlach, C., Swart, E., Sie, D., Nunes-Alves, C., Kerkhoven, R. M., Arens, R., Correia-Neves, M., Schepers, K., & Schumacher, T. N. M.
- Affiliations
- Department of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.
- The Netherlands Cancer Institute (NL)
- University of Minho (PT)
- Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal.
- Corresponding author
- Arens, Ramon
- Schepers, Koen
- Schumacher, Ton N. M.
- ORCID
- Venue
- Science
- Published
- 2009-09-04
- Volume
- 325
- Issue
- 5945
- Pages
- 1265-1269
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1996699270
- Cited by
- 146
- References
- 16
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 10 · 2019: 4 · 2018: 10 · 2017: 8 · 2016: 10 · 2015: 8 · 2014: 14 · 2013: 13 · 2012: 9
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- CD8+ T cells, antigen-specific T cell responses, clonal expansion, clonal selection, T cell proliferation, infection severity, T cell transfer
- MeSH terms
- Ampicillin, Animals, Anti-Bacterial Agents, Epitopes, Antigens, Antigens, Bacterial, Antigens, Viral, Dendritic Cells, Listeriosis, Lymphocyte Activation, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Orthomyxoviridae Infections, Influenza A virus, Ovalbumin, Spleen, Vaccinia, Virus Diseases, Receptors, Antigen, T-Cell, alpha-beta, CD8-Positive T-Lymphocytes, Lymphocyte Count, Adoptive Transfer, Genes, T-Cell Receptor alpha, Genes, T-Cell Receptor beta, Mice
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