The DOI matches its Crossref record; 22 of the 27 references it cites were found in a registry or an index.
Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
Open accessAbstract
When Polymerases Collide: Genomes must be replicated by DNA polymerase and copied by RNA polymerase. The two processes occur concurrently in bacteria and, although the majority of bacterial genes are co-oriented with replication, head-on collisions still occur and can result in double-strand breaks in the genome. Pomerantz and O'Donnell (p. 590 ) show, in vitro, that both Escherichia coli DNA and RNA polymerases grind to a halt when they collide bumper to bumper but that the replication fork remains intact, with the RNA polymerase being shunted off the DNA and out of the way. Mfd, a transcription-repair coupling factor, promotes DNA replication restart probably by rewinding separated DNA stands ahead of the halted transcription complex, promoting its displacement from the DNA.
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Citations
Cites
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The replisome uses mRNA as a primer after colliding with RNA polymerase
Pomerantz, R. T., & O’Donnell, M. E. (2008) · Nature · doi:10.1038/nature07527 · Cited by 190 · cited 1×
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Self-citationReplication fork barriers: pausing for a break or stalling for time?
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Self-citationAvoiding and resolving conflicts between DNA replication and transcription
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Flagged first, then by citations
5 of the 27 references couldn’t be matched to a known paper.
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Sorted by citations
A Whole-Cell Computational Model Predicts Phenotype from Genotype
Karr, J. R., Sanghvi, J. C., Macklin, D. N., Gutschow, M. V., Jacobs, J. M., Bolival, B., Assad-Garcia, N., Glass, J. I., & Covert, M. W. (2012) · Cell · doi:10.1016/j.cell.2012.05.044 · Cited by 1,300
“Previous researchers have studied the collisions of pairs of specific proteins (Pomerantz and O’Donnell, 2010), but experimentally determining the collisions among all pairs of DNA-binding proteins at the genomic scale at single-cell resolution is currently infeasible.”
Mfd Dynamically Regulates Transcription via a Release and Catch-Up Mechanism
Le, T. T., Yang, Y., Tan, C., Suhanovsky, M. M., Fulbright, R. M., Inman, J. T., Li, M., Lee, J., Perelman, S. E., Roberts, J. W., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.017 · Cited by 85
“Mfd can facilitate the removal of RNAP ahead of a replication fork in vitro, allowing replication to continue unimpeded (Pomerantz and O’Donnell, 2010), and to reduce double-stranded breaks that may result from collisions in vivo (Dutta et al.”
Mechanisms of trinucleotide repeat instability during human development
McMurray, C. T. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2828 · Cited by 496
Aguilera, A., & García-Muse, T. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133232 · Cited by 476
“It is possible that a fork traveling in the same direction as an elongating RNA polymerase may not stall that strongly or that the transient RNA-DNA hybrid formed as an intermediate of RNA synthesis may serve to reinitiate codirectional but not head-on replication (158, 159).”
R-loop-mediated genomic instability is caused by impairment of replication fork progressionPreprint
Gan, W., Guan, Z., Liu, J., Gui, T., Shen, K., Manley, J. L., & Xialu Li, C. (2011) · Genes & Development · doi:10.1101/gad.17010011 · Cited by 459
Metadata
- Authors
- Pomerantz, R. T., & O’Donnell, M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- O’Donnell, Mike
- Venue
- Science
- Published
- 2010-01-29
- Volume
- 327
- Issue
- 5965
- Pages
- 590-592
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2861996
- OpenAlex
- W2086307439
- Cited by
- 150
- References
- 27
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 10 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 15 · 2015: 9 · 2014: 7 · 2013: 17 · 2012: 14
- FWCI
- 7.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences (R01GM038839)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- replication fork restart, replication fork stalling, replisome, transcription-coupled repair, Mfd, Escherichia coli, DNA replication, transcription-replication conflict
- MeSH terms
- Bacterial Proteins, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, DNA, Bacterial, Escherichia coli, DNA-Directed RNA Polymerases, Templates, Genetic, Transcription Factors, Transcription, Genetic, Escherichia coli Proteins
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