The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus
Open accessAbstract
Swine Flu Neutralized: The 2009 H1N1 flu virus had an unusually low infection rate in elderly people. An antibody isolated from survivors of the 1918 flu pandemic was recently shown to cross-neutralize 2009 H1N1 viruses. Xu et al. (p. 357 , published online 25 March) report crystal structures of the virus envelope protein, hemagglutinin (HA) from 2009 H1N1 and of 1918 H1 HA in complex with a neutralizing antibody that cross-reacts with both pandemic viruses. These studies reveal an epitope that is conserved in the pandemic viruses, but divergent in other known H1 HAs, from the 1930s to the present. This antigenic similarity explains the age-related immunity to the 2009 H1N1 influenza.
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Cites
Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009
Jain, S., Kamimoto, L., Bramley, A. M., Schmitz, A. M., Benoit, S. R., Louie, J., Sugerman, D. E., Druckenmiller, J. K., Ritger, K. A., Chugh, R., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0906695 · Cited by 1,700
1918 Influenza: the Mother of All Pandemics
Taubenberger, J. K., & Morens, D. M. (2006) · Emerging Infectious Diseases · doi:10.3201/eid1201.050979 · Cited by 1,686
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Exploitation of glycosylation in enveloped virus pathobiology
Watanabe, Y., Bowden, T. A., Wilson, I. A., & Crispin, M. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.05.012 · Cited by 482
Self-citationSkowronski, D. M., Janjua, N. Z., De Serres, G., Sabaiduc, S., Eshaghi, A., Dickinson, J. A., Fonseca, K., Winter, A.-L., Gubbay, J. B., Krajden, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092153 · Cited by 416
Learning the language of viral evolution and escape
Hie, B., Zhong, E. D., Berger, B., & Bryson, B. (2021) · Science · doi:10.1126/science.abd7331 · Cited by 361
Sasaki, S., Sullivan, M., Narvaez, C. F., Holmes, T. H., Furman, D., Zheng, N.-Y., Nishtala, M., Wrammert, J., Smith, K., James, J. A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57834 · Cited by 300
Metadata
- Authors
- Xu, R., Ekiert, D. C., Krause, J. C., Hai, R., Crowe, J. E., & Wilson, I. A.
- Venue
- Science
- Published
- 2010-04-16
- Volume
- 328
- Issue
- 5976
- Pages
- 357-360
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2157116486
- Cited by
- 600
- References
- 2
- FWCI
- 50.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Xu, R., Ekiert, D. C., Krause, J. C., Hai, R., Crowe, J. E., & Wilson, I. A. (2010). Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus. Science. https://doi.org/10.1126/science.1186430
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