The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Genome-Wide Reprogramming in the Mouse Germ Line Entails the Base Excision Repair Pathway
Open accessAbstract
Erasing Markers: Epigenetic reprogramming of the mammalian genome, which involves the removal and replacement of the various regulatory epigenetic marks such as DNA methylation, occurs during germ cell differentiation and during early zygotic development. This process is also critical during the experimental generation of stem cells, but the factors and pathways that control epigenetic reprogramming are not well understood. Hajkova et al. (p. 78 ) investigated the erasure of DNA methylation during germ cell differentiation and during early zygotic development in the developing mouse and found that factors involved in the base excision repair (BER) pathway, which helps repair damaged DNA, were involved. Furthermore, inhibitors of BER resulted in the retention of DNA methylation in the zygote.
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Cites
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
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The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
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Demethylation of the zygotic paternal genome
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Epigenetic reprogramming in mouse primordial germ cells
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Self-citationActive demethylation of the paternal genome in the mouse zygote
Oswald, J., Engemann, S., Lane, N., Mayer, W., Olek, A., Fundele, R., Dean, W., Reik, W., & Walter, J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00448-6 · Cited by 981
Cyclical DNA methylation of a transcriptionally active promoter
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Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency
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Cited by
DNA methylation: roles in mammalian development
Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045
TET-mediated active DNA demethylation: mechanism, function and beyond
Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661
TET enzymes, TDG and the dynamics of DNA demethylation
Kohli, R. M., & Zhang, Y. (2013) · Nature · doi:10.1038/nature12750 · Cited by 1,623
Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
Wu, H., & Zhang, Y. (2014) · Cell · doi:10.1016/j.cell.2013.12.019 · Cited by 1,065
“5fC and 5caC generated from further oxidization of 5hmC provide a substrate for TDG-mediated 6, January 16, 2014 ª2014 Elsevier Inc. 57 excision repair pathway (Inoue et al., 2011), and there is some evidence supporting a role of BER in paternal genome demethylation (Hajkova et al., 2010).”
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Spruijt, C. G., Gnerlich, F., Smits, A. H., Pfaffeneder, T., Jansen, P. W. T. C., Bauer, C., Münzel, M., Wagner, M., Müller, M., Khan, F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.02.004 · Cited by 973
Metadata
- Authors
- Hajkova, P., Jeffries, S. J., Lee, C., Miller, N., Jackson, S. P., & Surani, M. A.
- Venue
- Science
- Published
- 2010-07-02
- Volume
- 329
- Issue
- 5987
- Pages
- 78-82
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026529460
- Cited by
- 473
- References
- 36
- FWCI
- 25.40
- Type
- journal article
- Language
- en
- Open access
- green
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