The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module
Open accessAbstract
Complex SAGA: The SAGA (Spt-Ada-Gcn5-Acetyltransferase) complex, which is conserved in eukaryotes, plays a key role in regulating gene expression. It is comprised of 21 proteins, and its functions include histone acetylation and deubiquitination. Samara et al. (p. 1025 , published online 15 April) now report the structure of the SAGA deubiquitinating module (DUBm), a four-protein subcomplex, both on its own and bound to ubiquitin aldehyde. The domains are interconnected and stabilized by eight zinc atoms. The organization gives insight into why DUBm complex formation is required to activate the catalytic domain of the enzyme and suggests how DUBm might bind to monoubiquitinated histones.
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Cites
Histones: annotating chromatin
Campos, E. I., & Reinberg, D. (2009) · Annual Review of Genetics · doi:10.1146/annurev.genet.032608.103928 · Cited by 852
Henry, K. W., Wyce, A., Lo, W.-S., Duggan, L. J., Emre, N. C. T., Kao, C.-F., Pillus, L., Shilatifard, A., Osley, M. A., & Berger, S. L. (2003) · Genes & Development · doi:10.1101/gad.1144003 · Cited by 714
Cited by
Multiple Functions of BCL-2 Family Proteins
Hardwick, J. M., & Soane, L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008722 · Cited by 564
Deubiquitylases From Genes to Organism
Clague, M. J., Barsukov, I., Coulson, J. M., Liu, H., Rigden, D. J., & Urbé, S. (2013) · Physiological Reviews · doi:10.1152/physrev.00002.2013 · Cited by 425
Lin, Z., Yang, H., Kong, Q., Li, J., Lee, S.-M., Gao, B., Dong, H., Wei, J., Song, J., Zhang, D. D., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.03.024 · Cited by 315
Henriksen, P., Wagner, S. A., Weinert, B. T., Sharma, S., Bačinskaja, G., Rehman, M., Juffer, A. H., Walther, T. C., Lisby, M., & Choudhary, C. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.017251 · Cited by 246
Wu, H.-T., Kuo, Y.-C., Hung, J.-J., Huang, C.-H., Chen, W.-Y., Chou, T.-Y., Chen, Y., Chen, Y.-J., Chen, Y.-J., Cheng, W.-C., et al. (2016) · Nature Communications · doi:10.1038/ncomms13644 · Cited by 129
Metadata
- Authors
- Samara, N. L., Datta, A. B., Berndsen, C. E., Zhang, X., Yao, T., Cohen, R. E., & Wolberger, C.
- Venue
- Science
- Published
- 2010-05-21
- Volume
- 328
- Issue
- 5981
- Pages
- 1025-1029
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2028140379
- Cited by
- 225
- References
- 2
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- green
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