The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics
Abstract
The Power Behind P450: Drugs, toxins and a range of metabolic substrates are detoxified in the liver by family of iron-containing enzymes called cytochrome P450. The iron component transfers oxygen to compounds that are often highly resistant to chemical reaction, but we know very little about the mechanism of this vital detoxification process. Rittle and Green (p. 933 ; see the Perspective by Sligar ) have managed to capture the P450 reaction intermediate by freezing a solution of the enzyme as it reacts with an oxidant. Spectroscopic techniques and kinetic studies then revealed an iron(IV)oxo intermediate that passes its oxygen along to the substrate with remarkable speed.
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Cites
Structure and chemistry of cytochrome p450
Denisov, I. G., Makris, T. M., Sligar, S. G., & Schlichting, I. (2005) · Chemical Reviews · doi:10.1021/cr0307143 · Cited by 2,106
Cited by
Heme Enzyme Structure and Function
Poulos, T. L. (2014) · Chemical Reviews · doi:10.1021/cr400415k · Cited by 1,443
Gregory, M. C., Denisov, I. G., Grinkova, Y. V., Khatri, Y., & Sligar, S. G. (2013) · Journal of the American Chemical Society · doi:10.1021/ja4086403 · Cited by 80
Davydov, R., Gilep, A. A., Strushkevich, N. V., Usanov, S. A., & Hoffman, B. M. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3067226 · Cited by 49
Zhao, B., Moody, S. C., Hider, R. C., Lei, L., Kelly, S. L., Waterman, M. R., & Lamb, D. C. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13078500 · Cited by 42
Oxidizing intermediates in p450 catalysis: A case for multiple oxidants
Modi, A. R., & Dawson, J. H. (2015) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-16009-2_2 · Cited by 32
Metadata
- Authors
- Rittle, J., & Green, M. T.
- Venue
- Science
- Published
- 2010-11-12
- Volume
- 330
- Issue
- 6006
- Pages
- 933-937
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968400590
- Cited by
- 1,368
- References
- 1
- FWCI
- 46.20
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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