Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis
Open accessAbstract
Infectious Amyloid?: Patients with Alzheimer's disease have characteristic lesions in the brains associated with masses of polymerized protein called β-amyloid. Recently, evidence from mouse models of Alzheimer's disease shows that brain extracts containing β-amyloid can “infect” otherwise healthy animals when injected directly into their brains. Eisele et al. (p. 980 , published online 21 October; see the Perspective by Kim and Holtzman ) extend these findings to show that when mice are injected in other parts of their bodies with similar brain extracts after several months, they also develop amyloidosis within their brains.
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Peripherally derived Aβ enters the brain and exacerbates neuropathology.
“Furthermore, peripherally derived Aβ has been shown to enter the brain and exacerbate neuropathology, further supporting the importance of peripheral Aβ stores and clearance [25].”
From Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner (2024) · cites this paper as [25]
The paper reports that intraperitoneal injection of Aβ-rich brain extract induced cerebral β-amyloidosis and associated pathologies in APP23 mice (Abstract; no page provided). It says the injected material was likely carried to the brain, but does not demonstrate its entry or establish that naturally occurring peripheral Aβ stores have the same effect. (LLM, conf=0.85)
Experimental — accuracy not yet measuredDirect introduction of the seeding agent into the brain is the most efficient way to induce prion disease and Aβ deposition.
“The most efficient induction of prion disease and Aβ deposition is achieved by direct introduction of the seeding agent into the brain30, 56.”
From Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders (2011) · cites this paper as [56]
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References 15 · Cited by 568
Research works printed but not linked: 3
- [1]Meyer-Lühmann M Science 131 1781 2006 16990547
- [3]Prusiner SB Prion Biology and Diseases Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY 2 2004
- [12]Sorandt M Mintun MA Head D Morris JC Arch Neurol 66 1476 2009 20008651 PMC2796577
- Authors
- Eisele, Y. S., Obermüller, U., Heilbronner, G., Baumann, F., Kaeser, S. A., Wolburg, H., Walker, L. C., Staufenbiel, M., Heikenwalder, M., & Jucker, M.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- University of Tübingen (DE)
- Emory University (US)
- Novartis (Switzerland) (CH)
- Department of Pathology, Institute for Neuropathology, University Hospital, CH-8091 Zürich, Switzerland.
- Corresponding author
- Jucker, Mathias
- ORCID
- Venue
- Science
- Published
- 2010-11-12
- Volume
- 330
- Issue
- 6006
- Pages
- 980-982
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3233904
- OpenAlex
- W1493986974
- Cited by
- 568
- References
- 15
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 27 · 2023: 27 · 2022: 30 · 2021: 32 · 2020: 47 · 2019: 39 · 2018: 33 · 2017: 36 · 2016: 43 · 2015: 46 · 2014: 40 · 2013: 50 · 2012: 51
- FWCI
- 31.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Site cant be reached (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- National Center for Research Resources (RR-00 165, P51RR000165)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amyloid-beta, cerebral amyloidosis, brain extracts, transneuronal spread, mouse model, prion-like propagation
- MeSH terms
- Alzheimer Disease, Animals, Brain, Brain Chemistry, Female, Injections, Intraperitoneal, Mice, Transgenic, Prions, Time Factors, Amyloid beta-Peptides, Cerebral Amyloid Angiopathy, Protein Folding, Mice, Plaque, Amyloid
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