The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist
Open accessAbstract
Tweaking Dopamine Reception: Dopamine modulates many cognitive and emotional functions of the human brain by activating G protein–coupled receptors. Antipsychotic drugs that block two of the receptor subtypes are used to treat schizophrenia but have multiple side effects. Chien et al. (p. 1091 ; see the Research Article by Wu et al. ) resolved the crystal structure of one receptor in complex with a small-molecule inhibitor at 3.15 angstrom resolution. Homology modeling with other receptor subtypes might be a promising route to reveal potential structural differences that can be exploited in the design of selective therapeutic inhibitors having fewer side effects.
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Cites
Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor
Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Trong, I. L., Teller, D. C., Okada, T., Stenkamp, R. E., et al. (2000) · Science · doi:10.1126/science.289.5480.739 · Cited by 5,637
The Retinal Conformation and its Environment in Rhodopsin in Light of a New 2.2 Å Crystal Structure
Okada, T., Sugihara, M., Bondar, A.-N., Elstner, M., Entel, P., & Buss, V. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.07.044 · Cited by 1,049
Dopamine D3Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats
Vorel, S. R., Ashby, C. R., Paul, M., Liu, X., Hayes, R., Hagan, J. J., Middlemiss, D. N., Stemp, G., & Gardner, E. L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09595.2002 · Cited by 269
Cited by
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
Lebon, G., Warne, T., Edwards, P. C., Bennett, K., Langmead, C. J., Leslie, A. G. W., & Tate, C. G. (2011) · Nature · doi:10.1038/nature10136 · Cited by 873
Sun, F., Zeng, J., Jing, M., Zhou, J., Feng, J., Owen, S. F., Luo, Y., Li, F., Wang, H., Yamaguchi, T., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.042 · Cited by 837
Structure of the human histamine H1 receptor complex with doxepin
Shimamura, T., Shiroishi, M., Weyand, S., Tsujimoto, H., Winter, G., Katritch, V., Abagyan, R., Cherezov, V., Liu, W., Han, G. W., et al. (2011) · Nature · doi:10.1038/nature10236 · Cited by 804
Self-citationA Survey of the Role of Noncovalent Sulfur Interactions in Drug Design
Beno, B. R., Yeung, K.-S., Bartberger, M. D., Pennington, L. D., & Meanwell, N. A. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501853m · Cited by 772
How Ligands Illuminate GPCR Molecular Pharmacology
Wacker, D., Stevens, R. C., & Roth, B. L. (2017) · Cell · doi:10.1016/j.cell.2017.07.009 · Cited by 560
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Metadata
- Authors
- Chien, E. Y. T., Liu, W., Zhao, Q., Katritch, V., Won Han, G., Hanson, M. A., Shi, L., Newman, A. H., Javitch, J. A., Cherezov, V., & Stevens, R. C.
- Venue
- Science
- Published
- 2010-11-19
- Volume
- 330
- Issue
- 6007
- Pages
- 1091-1095
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2104961861
- Cited by
- 1,128
- References
- 3
- FWCI
- 52.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Chien, E. Y. T., Liu, W., Zhao, Q., Katritch, V., Won Han, G., Hanson, M. A., Shi, L., Newman, A. H., Javitch, J. A., Cherezov, V., & Stevens, R. C. (2010). Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist. Science. https://doi.org/10.1126/science.1197410
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
