Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

Malik, Fady I.; Hartman, James J.; Elias, Kathleen A.; Morgan, Bradley P.; Rodriguez, Hector; Brejc, Katjuša; Anderson, Robert L.; Sueoka, Sandra H.; Lee, Kenneth H.; Finer, Jeffrey T.; Sakowicz, Roman; Baliga, Ramesh; Cox, David R.; Garard, Marc; Godinez, Guillermo; Kawas, Raja; Kraynack, Erica; Lenzi, David; Lu, Pu Ping; Muci, Alexander; Niu, Congrong; Qian, Xiangping; Pierce, Daniel W.; Pokrovskii, Maria; Suehiro, Ion; Sylvester, Sheila; Tochimoto, Todd; Valdez, Corey; Wang, Wenyue; Katori, Tatsuo; Kass, David A.; Shen, You-Tang; Vatner, Stephen F.; Morgans, David J.

doi:10.1126/science.1200113

Cited by 584

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

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Malik, Fady I., Hartman, James J., Elias, Kathleen A., Morgan, Bradley P., Rodriguez, Hector, Brejc, Katjuša, Anderson, Robert L., Sueoka, Sandra H., Lee, Kenneth H., Finer, Jeffrey T., Sakowicz, Roman, Baliga, Ramesh, Cox, David R., Garard, Marc, Godinez, Guillermo, Kawas, Raja, Kraynack, Erica, Lenzi, David, Lu, Pu Ping, Muci, Alexander, Niu, Congrong, Qian, Xiangping, Pierce, Daniel W., Pokrovskii, Maria, Suehiro, Ion, Sylvester, Sheila, Tochimoto, Todd, Valdez, Corey, Wang, Wenyue, Katori, Tatsuo, Kass, David A., Shen, You-Tang, Vatner, Stephen F., Morgans, David J.·2011·Science

DOI 10.1126/science.1200113

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A small molecule improves cardiac function by accelerating the transition of myosin into a force-producing state.

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Crossref · 10.1126/science.1200113

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22 of 22 references verified0 citation errors · 0 not checkable

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Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700
Characteristics and outcomes of patients hospitalized for heart failure in the United States: Rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)
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Executive Summary: Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
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Instantaneous Pressure-Volume Relationships and Their Ratio in the Excised, Supported Canine Left Ventricle
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Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy
Grimsby, J., Sarabu, R., Corbett, W. L., Haynes, N.-E., Bizzarro, F. T., Coffey, J. W., Guertin, K. R., Hilliard, D. W., Kester, R. F., Mahaney, P. E., et al. (2003) · Science · doi:10.1126/science.1084073 · Cited by 526
Direct, Real-Time Measurement of Rapid Inorganic Phosphate Release Using a Novel Fluorescent Probe and Its Application to Actomyosin Subfragment 1 ATPase
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Systolic Heart Failure
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Show all 22 references

Mitochondrial function as a therapeutic target in heart failure
Brown, D. A., Perry, J. B., Allen, M. E., Sabbah, H. N., Stauffer, B. L., Shaikh, S. R., Cleland, J. G. F., Colucci, W. S., Butler, J., Voors, A. A., et al. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.203 · Cited by 803
Pathological Ventricular Remodeling: Mechanisms: Part 1 of 2
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Heart Failure
Braunwald, E. (2013) · JACC: Heart Failure · doi:10.1016/j.jchf.2012.10.002 · Cited by 730
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Green, E. M., Wakimoto, H., Anderson, R. L., Evanchik, M. J., Gorham, J. M., Harrison, B. C., Henze, M., Kawas, R., Oslob, J. D., Rodriguez, H. M., et al. (2016) · Science · doi:10.1126/science.aad3456 · Cited by 707
Self-citation
Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure
Teerlink, J. R., Diaz, R., Felker, G. M., McMurray, J. J. V., Metra, M., Solomon, S. D., Adams, K. F., Anand, I., Arias-Mendoza, A., Biering-Sørensen, T., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2025797 · Cited by 656
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Authors: Malik, F. I., Hartman, J. J., Elias, K. A., Morgan, B. P., Rodriguez, H., Brejc, K., Anderson, R. L., Sueoka, S. H., Lee, K. H., Finer, J. T., Sakowicz, R., Baliga, R., Cox, D. R., Garard, M., Godinez, G., Kawas, R., Kraynack, E., Lenzi, D., Lu, P. P., Muci, A., Niu, C., Qian, X., Pierce, D. W., Pokrovskii, M., Suehiro, I., Sylvester, S., Tochimoto, T., Valdez, C., Wang, W., Katori, T., Kass, D. A., Shen, Y.-T., Vatner, S. F., & Morgans, D. J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2011-03-18
Volume: 331
Issue: 6023
Pages: 1439-1443
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1200113
OpenAlex: W2077146886
Cited by: 584
References: 22
FWCI: 23.38
Type: journal article
Language: en
Open access: green

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This page: CoChat. (2026). Citation check: Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure. https://app.cochat.ai/papers/10.1126/science.1200113
The paper: Malik, F. I., Hartman, J. J., Elias, K. A., Morgan, B. P., Rodriguez, H., Brejc, K., Anderson, R. L., Sueoka, S. H., Lee, K. H., Finer, J. T., Sakowicz, R., Baliga, R., Cox, D. R., Garard, M., Godinez, G., Kawas, R., Kraynack, E., Lenzi, D., Lu, P. P., . . . Morgans, D. J. (2011). Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure. Science. https://doi.org/10.1126/science.1200113

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Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

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