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Cited by 540Cancer-related molecular mechanisms researchGenomics and Chromatin DynamicsChromosomal and Genetic Variations

Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers

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Ting, David T., Lipson, Doron, Paul, Suchismita, Brannigan, Brian W., Akhavanfard, Sara, Coffman, Erik J., Contino, Gianmarco, Deshpande, Vikram +6 more·2011·Science
DOI 10.1126/science.1200801PMC PMC3701432
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Abstract

Noncoding RNAs transcribed from DNA repeats in heterochromatin are expressed at surprisingly high levels in tumors.

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  • Noncoding hSATII RNA is highly expressed in most cancer cells and tissues.

    “Previous reports demonstrated that noncoding hSATII RNA is highly expressed in most cancer cells and tissues (27–32).”

    From Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment (2023) · cites this paper as [27]

    The paper reports high HSATII expression in human pancreatic cancers and in sampled lung, kidney, ovarian, and prostate cancers (section labeled Abstract; page unavailable). It does not establish that HSATII is highly expressed in most cancer cells or across most cancer tissues. Its finding of expression in all cells within tumors concerns mouse major satellite RNA, not human HSATII. (LLM, conf=0.85)

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References 23 · Cited by 540

Research works printed but not linked: 23

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Authors
Ting, D. T., Lipson, D., Paul, S., Brannigan, B. W., Akhavanfard, S., Coffman, E. J., Contino, G., Deshpande, V., Iafrate, A. J., Letovsky, S., Rivera, M. N., Bardeesy, N., Maheswaran, S., & Haber, D. A.
Affiliations
  • Harvard University (US)
  • Helicos Biosciences (United States) (US)
Corresponding author
  • Ting, David T.
  • Lipson, Doron
  • Haber, Daniel A.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2011-02-04
Volume
331
Issue
6017
Pages
593-596
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1200801
PMC
PMC3701432
OpenAlex
W2056925335
Cited by
540
References
23
Citations by year
2026: 15 · 2025: 31 · 2024: 27 · 2023: 30 · 2022: 48 · 2021: 62 · 2020: 41 · 2019: 31 · 2018: 26 · 2017: 31 · 2016: 22 · 2015: 30 · 2014: 40 · 2013: 32 · 2012: 49
FWCI
15.78
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Cancer Institute (L30 CA142210, CA-129933, R01CA129933, P01CA117969)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Keywords
satellite repeats, pericentromeric heterochromatin, LINE-1 retrotransposons, pancreatic ductal adenocarcinoma, epithelial cancers, non-coding RNA, gene silencing, tumor markers
MeSH terms
Animals, Carcinoma in Situ, Colonic Neoplasms, DNA, Neoplasm, DNA, Satellite, Female, Heterochromatin, Humans, Lung Neoplasms, Male, Mice, Nude, Neoplasms, Neurosecretory Systems, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, RNA, Neoplasm, Transcription, Genetic, Gene Expression, DNA Methylation, Long Interspersed Nucleotide Elements, Gene Expression Profiling, Carcinoma, Pancreatic Ductal, RNA, Untranslated, Mice

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