The DOI matches its Crossref record.
Comment on “A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus”
Abstract
Wolfe-Simon et al . (Research Articles, 3 June 2011, p. 1163; published online 2 December 2010) reported that bacterium GFAJ-1 can substitute arsenic for phosphorus in its macromolecules, including DNA and proteins. If such arseno-DNA exists, then much of the past century of work with arsenate and phosphate chemistry, as well as much of what we think we know about metabolism, will need rewriting.
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The claims that a bacterium could substitute arsenic for phosphorus in its DNA have been largely rejected by the scientific community as not proven by the evidence presented.
“These claims have been largely rejected by the scientific community, which has generally concluded that they are not proven by the evidence presented in the paper (Benner, 2011; Borhani, 2011; Cotner and Hall, 2011; Csabai and Szathmáry, 2011; Foster, 2011; Oehler, 2011; Redfield, 2011; Schoepp-Cothenet et al., 2011; Erb et al., 2012; Reaves et al., 2012).”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Benner, 2011
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Domagal-Goldman, S. D., Wright, K. E., Domagal-Goldman, S. D., Wright, K. E., Adamala, K., Arina de la Rubia, L., Bond, J., Dartnell, L. R., Goldman, A. D., Lynch, K., et al. (2016) · Astrobiology · doi:10.1089/ast.2015.1460 · Cited by 136
Metadata
- Authors
- Benner, S. A.
- Affiliations
- Foundation for Applied Molecular Evolution (US)
- Corresponding author
- Benner, Steven A.
- ORCID
- Benner, Steven A.
- Venue
- Science
- Published
- 2011-06-03
- Volume
- 332
- Issue
- 6034
- Pages
- 1149-1149
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4250659269
- Cited by
- 37
- References
- 0
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
- Physical Sciences › Chemistry › Inorganic Chemistry › Synthesis and characterization of novel inorganic/organometallic compounds
- Keywords
- arsenate, microbial metabolism, phosphate chemistry
- MeSH terms
- Arsenates, Arsenic, DNA, Bacterial, Hydrolysis, Phosphates, Phosphorus, Halomonadaceae
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