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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4

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Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

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Plat-E: an efficient and stable system for transient packaging of retroviruses

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Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies

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CD28 and CTLA-4 coreceptor expression and signal transduction

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Foxp3 + natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

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B cells acquire antigen from target cells after synapse formation

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A MOLECULAR PERSPECTIVE OF CTLA-4 FUNCTION

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IL36 Cooperates With Anti-CTLA-4 mAbs to Facilitate Antitumor Immune Responses

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The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity

Hsu, Y. O., Lu, K., Fu, Y., Wang, C., Lu, C., Lin, Y., Chang, W.-C., Yeh, K., Chung, W., Chung, W., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.597761 · Cited by 32

Recent Advances on Immune Targeted Therapy of Colorectal Cancer Using bi-Specific Antibodies and Therapeutic Vaccines

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Insights into Potential Pathogenesis and Treatment Options for Immune-Checkpoint Inhibitor-Related Pneumonitis

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Regulatory T-Cell Therapy in Liver Transplantation and Chronic Liver Disease

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Beyond adjuvants: Immunomodulation strategies to enhance T cell immunity

Kamphorst, A. O., Araki, K., & Ahmed, R. (2015) · Vaccine · doi:10.1016/j.vaccine.2014.12.082 · Cited by 31

Harnessing the immune system by targeting immune checkpoints: Providing new hope for Oncotherapy

Yu, L., Sun, M., Zhang, Q., Zhou, Q., & Wang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.982026 · Cited by 32

Candida-Elicited Murine Th17 Cells Express High CTLA-4 Compared with Th1 Cells and Are Resistant to Costimulation Blockade

Krummey, S. M., Floyd, T. L., Liu, D., Wagener, M. E., Song, M., & Ford, M. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301332 · Cited by 31

Bioinformatics analysis and experimental validation of cuproptosis-related lncRNA LINC02154 in clear cell renal cell carcinoma

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Melanoma: oncogenic drivers and the immune system.

Karachaliou, N., Pilotto, S., Teixidó, C., Viteri, S., González‐Cao, M., Riso, A. A., Morales-Espinosa, D., Molina‐Vila, M. Á., CHAIB-OUKADOUR, I., Santarpía, M., et al. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.08.06 · Cited by 30

T regulatory cells: Achilles’ heel of Mycobacterium tuberculosis infection?

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Unregulated antigen-presenting cell activation by T cells breaks self tolerance

Yi, J., Jung, J., Hong, S., Lee, J. Y., Han, D., Kim, K. S., Sprent, J., & Surh, C. D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818624116 · Cited by 30

Targeting Multiple Receptors to Increase Checkpoint Blockade Efficacy

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CTLA-4 antibody ipilimumab negatively affects CD4+ T-cell responses in vitro

Rosskopf, S., Leitner, J. M., Zlabinger, G. J., & Steinberger, P. (2019) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-019-02369-x · Cited by 31

Vitamin D3-mediated resistance to a multiple sclerosis model disease depends on myeloid cell 1,25-dihydroxyvitamin D3 synthesis and correlates with increased CD4+ T cell CTLA-4 expression

Spanier, J. A., Nashold, F. E., Nelson, C. D., Praska, C. E., & Hayes, C. E. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.577105 · Cited by 31

One, No One, and One Hundred Thousand: T Regulatory Cells' Multiple Identities in Neuroimmunity

Sambucci, M., Gargano, F., Guerrera, G., Battistini, L., & Borsellino, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02947 · Cited by 31

Clinical Phenotypes and Immunological Characteristics of 18 Egyptian LRBA Deficiency Patients

Meshaal, S. S., Hawary, R. E., Adel, R., Elaziz, D. S. A., Erfan, A., Lotfy, S., Hafez, M. M., Hassan, M. M., Johnson, M. B., Rojas‐Restrepo, J., et al. (2020) · Journal of Clinical Immunology · doi:10.1007/s10875-020-00799-2 · Cited by 30

Review article: experimental therapies in autoimmune hepatitis

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Blood PD-1+TFh and CTLA-4+CD4+ T cells predict remission after CTLA-4Ig treatment in early rheumatoid arthritis

Aldridge, J., Andersson, K. M., Gjertsson, I., Ekwall, A. H., Hallström, M., van Vollenhoven, R., Lundell, A., & Rudin, A. (2021) · Lara D. Veeken · doi:10.1093/rheumatology/keab454 · Cited by 30

Dynamics and epigenetic signature of regulatory T-cells following antiretroviral therapy initiation in acute HIV infection

Yero, A., Shi, T., Farnós, O., Routy, J., Tremblay, C., Durand, M., Tsoukas, C., Costiniuk, C., & Jenabian, M.-A. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103570 · Cited by 29

CD40-CD154: A perspective from type 2 immunity

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A mouse model of the LEAP study reveals a role for CTLA-4 in preventing peanut allergy induced by environmental peanut exposure

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Phagocytosing differentiated cell-fragments is a novel mechanism for controlling somatic stem cell differentiation within a short time frame

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Oral Delivery of a Probiotic Induced Changes at the Nasal Mucosa of Seasonal Allergic Rhinitis Subjects after Local Allergen Challenge: A Randomised Clinical Trial

Ivory, K., Wilson, A. M., Sankaran, P., Westwood, M., McCarville, J. L., Brockwell, C., Clark, A., Dainty, J. R., Zuidmeer, L., & Nicoletti, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078650 · Cited by 30

Nivolumab for treating non-small cell lung cancer

Guibert, N. M., & Mazières, J. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1114097 · Cited by 31

Interaction of molecular alterations with immune response in melanoma

Sloane, R. A. S., Gopalakrishnan, V., Reddy, S. M., Zhang, X., Reuben, A., & Wargo, J. A. (2017) · Cancer · doi:10.1002/cncr.30681 · Cited by 31

Is Graves’ disease a primary immunodeficiency? New immunological perspectives on an endocrine disease

Struja, T., Kutz, A., Fischli, S., Meier, C., Müeller, B., Recher, M., & Schüetz, P. (2017) · BMC Medicine · doi:10.1186/s12916-017-0939-9 · Cited by 30

Requirement of Treg-intrinsic CTLA4/PKCη signaling pathway for suppressing tumor immunity

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CTLA‑4 interferes with the HBV‑specific T�cell immune response (Review)

Cao, H., Zhang, R., & Zhang, W. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3688 · Cited by 32

Unleashing the efficacy of immune checkpoint inhibitors for advanced hepatocellular carcinoma: factors, strategies, and ongoing trials

Yu, J., Li, M., Ren, B., Cheng, L., Wang, X., Ma, Z., Yong, W. P., Chen, X., Wang, L., & Goh, B. C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1261575 · Cited by 31

Unveiling the role of regulatory T cells in the tumor microenvironment of pancreatic cancer through single-cell transcriptomics and in vitro experiments

Xu, W., Zhang, W., Zhao, D., Wang, Q., Zhang, M., Li, Q., Zhu, W., & Xu, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1242909 · Cited by 31

Nanobody-based CTLA4 inhibitors for immune checkpoint blockade therapy of canine cancer patients

Marable, J., Ruiz, D., Jaiswal, A. K., Bhattacharya, R., Pantazes, R. J., Agarwal, P., Suryawanshi, A. S., Bedi, D., Mishra, A., Smith, B. F., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-00325-3 · Cited by 29

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Bell, M. R., & Kutzler, M. A. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114175 · Cited by 29

Modern Immunotherapy in the Treatment of Triple-Negative Breast Cancer

Wesolowski, J., Tankiewicz‐Kwedlo, A., & Pawlak, D. (2022) · Cancers · doi:10.3390/cancers14163860 · Cited by 33

Genetic engineering with T cell receptors

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Immune Checkpoint Inhibitors: Therapeutic Tools for Breast Cancer

Su, M., Huang, C., & Dai, A.-P. (2016) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2016.17.3.905 · Cited by 29

Regulatory T-cell dynamics with abatacept treatment in rheumatoid arthritis

Langdon, K., & Haleagrahara, N. (2018) · International Reviews of Immunology · doi:10.1080/08830185.2018.1465943 · Cited by 30

Indirect suppression of CD4 T cell activation through LAG-3-mediated trans-endocytosis of MHC class II

Wakamatsu, E., Machiyama, H., Toyota, H., Takeuchi, A., Hashimoto, R., Kozono, H., & Yokosuka, T. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114655 · Cited by 28

Recent developments in the use of immunotherapy in non-small cell lung cancer

Santarpía, M., Giovannetti, E., Rolfo, C. D., Karachaliou, N., González‐Cao, M., Altavilla, G., & Rosell, R. (2016) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2016.1182866 · Cited by 28

Checkpoint Inhibitor-Induced Colitis—A Clinical Overview of Incidence, Prognostic Implications and Extension of Current Treatment Options

Portenkirchner, C., Kienle, P., & Horisberger, K. (2021) · Pharmaceuticals · doi:10.3390/ph14040367 · Cited by 29

Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity

Morimoto, J. O., Matsumoto, M., Miyazawa, R., Yoshida, H., Tsuneyama, K., & Matsumoto, M. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110384 · Cited by 28

Functional Diversities of Regulatory T Cells in the Context of Cancer Immunotherapy

Gao, R., Shi, G., & Wang, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.833667 · Cited by 29

Protective Effect of Poria Cocos Polysaccharides on Fecal Peritonitis-Induced Sepsis in Mice Through Inhibition of Oxidative Stress, Inflammation, Apoptosis, and Reduction of Treg Cells

Wu, Y. C., Li, D., Wang, H., & Wan, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.887949 · Cited by 28

Impact of disease-modifying therapy on dendritic cells and exploring their immunotherapeutic potential in multiple sclerosis

Liu, C., Zhu, J., Mi, Y., & Jin, T. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02663-z · Cited by 29

Checkpoint Inhibitor-Induced Colitis: From Pathogenesis to Management

Terrin, M., Migliorisi, G., Buono, A. D., Gabbiadini, R., Mastrorocco, E., Quadarella, A., Repici, A., Santoro, A., & Armuzzi, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411504 · Cited by 30

Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in infants

Rabe, H., Lundell, A., Andersson, K., Adlerberth, I., Wold, A. E., & Rudin, A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0511244 · Cited by 28

Immune Response Activation

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Vedolizumab as a successful treatment of CTLA-4–associated autoimmune enterocolitis

Navarini, A. A., Hruz, P. L., Berger, C. T., Hou, T. Z., Schwab, C., Gabrysch, A., Higgins, R., Frede, N., Sgier, B.-C. P., Kämpe, O., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.08.042 · Cited by 28

Memory T‐cell exhaustion and tolerance in transplantation

Hartigan, C. R., Sun, H. Y., & Ford, M. L. (2019) · Immunological Reviews · doi:10.1111/imr.12824 · Cited by 28

T Lymphocyte–Based Cancer Immunotherapeutics

Borrie, A. E., & Vareki, S. M. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.010 · Cited by 27

Gut microbiome on immune checkpoint inhibitor therapy and consequent immune-related colitis: a review

Hwang, S. W., Kim, M. K., & Kweon, M. (2023) · Intestinal Research · doi:10.5217/ir.2023.00019 · Cited by 28

Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape

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T-cell co-stimulatory blockade in transplantation: two steps forward one step back!

Riella, L. V., & Sayegh, M. H. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.845661 · Cited by 28

Potential cardiac risk of immune‐checkpoint blockade as anticancer treatment: What we know, what we do not know, and what we can do to prevent adverse effects

Spallarossa, P., Meliota, G., Brunelli, C., Arboscello, E., Ameri, P., Dessalvi, C. C., Grossi, F., Deidda, M., Mele, D., Sarocchi, M., et al. (2017) · Medicinal Research Reviews · doi:10.1002/med.21478 · Cited by 27

Mesenchymal Stem Cells Derived and Cultured from Glioblastoma Multiforme Increase Tregs, Downregulate Th17, and Induce the Tolerogenic Phenotype of Monocyte-Derived Cells

Tumangelova-Yuzeir, K. D., Naydenov, E., Ivanova‐Todorova, E., Krasimirova, E., Vasilev, G., Nachev, S., & Kyurkchiev, D. S. (2019) · Stem Cells International · doi:10.1155/2019/6904638 · Cited by 27

Comprehensive Targeted Sequencing Identifies Monogenic Disorders in Patients With Early‐onset Refractory Diarrhea

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Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma

Krebs, F. K., Trzeciak, E. R., Zimmer, S., Özistanbullu, D., Mitzel-Rink, H., Meißner, M., Grabbe, S., Loquai, C., & Tuettenberg, A. (2021) · Cancer Medicine · doi:10.1002/cam4.3710 · Cited by 28

Adoptive Transfer of Regulatory Immune Cells in Organ Transplantation

Oberholtzer, N. P., Atkinson, C., & Nadig, S. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.631365 · Cited by 28

Checkpoint blockade toxicities: Insights into autoimmunity and treatment

Walsh, M. J., & Dougan, M. L. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101473 · Cited by 27

M5C regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in lung adenocarcinoma

Chen, H., Ge, X., Zhang, Z., Liu, M., Wu, R., Zhang, X.-F., Xu, L., Cheng, H.-Y., Sun, X.-C., & Zhu, H. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-21-351 · Cited by 27

Motility Dynamics of T Cells in Tumor-Draining Lymph Nodes: A Rational Indicator of Antitumor Response and Immune Checkpoint Blockade

Kanda, Y., Okazaki, T., & Katakai, T. (2021) · Cancers · doi:10.3390/cancers13184616 · Cited by 30

Checkpoint: Inspecting the barriers in glioblastoma immunotherapies

Preddy, I., Nandoliya, K. R., Miska, J. M., & Ahmed, A. U. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.02.012 · Cited by 27

The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors

Luksik, A. S., Maxwell, R., Garzón-Muvdi, T., & Lim, M. K. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0513-3 · Cited by 27

TLR4 signaling improves PD-1 blockade therapy during chronic viral infection

Wang, Y., Chung, Y. R., Eitzinger, S., Palacio, N. M., Gregory, S., Bhattacharyya, M., & Penaloza‐MacMaster, P. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007583 · Cited by 24

Tolerogenic dendritic cells in type 1 diabetes: no longer a concept

Giannoukakis, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1212641 · Cited by 25

Inhibitory CARs fail to protect from immediate T cell cytotoxicity

Funk, M. A., Heller, G., Waidhofer‐Söllner, P., Leitner, J. M., & Steinberger, P. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.02.022 · Cited by 26

An update on the clinical trial research of immunotherapy for glioblastoma

Zhou, Y., Shi, F., Zhu, J., & Yuan, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1582296 · Cited by 31

The delicate balance of melanoma immunotherapy

Gyorki, D. E., Callahan, M. K., Wolchok, J. D., & Ariyan, C. E. (2013) · Clinical & Translational Immunology · doi:10.1038/cti.2013.5 · Cited by 26

The Role of MicroRNAs in Development and Function of Regulatory T Cells – Lessons for a Better Understanding of MicroRNA Biology

Kunze‐Schumacher, H., & Krueger, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02185 · Cited by 26

Immune Checkpoints, Inhibitors and Radionuclides in Prostate Cancer: Promising Combinatorial Therapy Approach

Kgatle, M., Boshomane, T. M. G., Lawal, I. O., Mokoala, K. M. G., Mokgoro, N. P., Lourens, N., Kairemo, K., Zeevaart, J. R., Vorster, M., & Sathekge, M. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084109 · Cited by 26

Immune checkpoint inhibitors for the treatment of myeloma: novel investigational options

Calvez, B. L., Moreau, P., & Touzeau, C. (2021) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2021.1955103 · Cited by 28

Tumor immunotherapy: Mechanisms and clinical applications

Nong, C., Guan, P., Li, L., Zhang, H., & Hu, H. (2022) · MedComm – Oncology · doi:10.1002/mog2.8 · Cited by 27

Advances in immune checkpoint inhibitors induced-cardiotoxicity

Li, X., Peng, W., Wu, J., Yeung, S. J., & Yang, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1130438 · Cited by 28

Targeting the Alternatively Spliced Soluble Isoform of CTLA-4: Prospects for Immunotherapy?

Ward, F. J., Dahal, L. N., Khanolkar, R. C., Shankar, S. P., & Barker, R. N. (2014) · Immunotherapy · doi:10.2217/imt.14.73 · Cited by 27

Fast and fierce versus slow and smooth: Heterogeneity in immune responses to Plasmodium in the controlled human malaria infection model

Yap, X. Z., McCall, M. B. B., & Sauerwein, R. W. (2019) · Immunological Reviews · doi:10.1111/imr.12811 · Cited by 27

Germinal Centre Shutdown

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Rewiring the T cell-suppressive cytokine landscape of the tumor microenvironment: a new frontier for precision anti-cancer therapy

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The ‘Treg paradox’ in inflammatory arthritis

Schnell, J. T., Briviesca, R. L., Kim, T., Charbonnier, L., Henderson, L. A., van Wijk, F., & Nigrovic, P. A. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01190-w · Cited by 27

Unravelling T cell exhaustion through co‐inhibitory receptors and its transformative role in cancer immunotherapy

Xiang, S., Li, S., & Xu, J. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70345 · Cited by 28

A review of immune checkpoint inhibitor-associated myocarditis: Epidemiology, pathogenesis, and biomarkers

Xu, L., Chen, Y., Xiong, L., Shen, Y., Zhou, Z., Wang, S., & Xu, X. (2025) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2025.2512645 · Cited by 32

Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis

Schlereth, S. L., Refaian, N., Iden, S., Cursiefen, C., & Heindl, L. M. (2014) · BioMed Research International · doi:10.1155/2014/639058 · Cited by 25

Immunotherapy a New Hope for Cancer Treatment: A Review

Rouz, F. N., Shirkhoda, M., Memari, F., Dana, H., Chalbatani, G. M., Mahmoodzad, H., Samarghand, N., Gharagozlo, E., Mohammadi, M. H., Maleki, A. R., et al. (2018) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2018.135.150 · Cited by 25

CTLA-4 Immunohistochemistry and Quantitative Image Analysis for Profiling of Human Cancers

Brown, C., Sekhavati, F., Cárdenes, R., Windmueller, C., Dacosta, K., Rodriguez‐Canales, J., & Steele, K. E. (2019) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155419882292 · Cited by 24

In Vivo Imaging of Local Inflammation: Monitoring LPS-Induced CD80/CD86 Upregulation by PET

Taddio, M. F., Jaramillo, C. A. C., Runge, P., Blanc, A., Keller, C., Talip, Z., Béhé, M. P., van der Meulen, N. P., Halin, C., Schibli, R., et al. (2020) · Molecular Imaging and Biology · doi:10.1007/s11307-020-01543-3 · Cited by 26

Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer

van der Gracht, E. T. I., Schoonderwoerd, M. J. A., van Duikeren, S., Yilmaz, A. N., Behr, F. M., Colston, J., Lee, L. N., Yagita∥, H., van Gisbergen, K. P. J. M., Hawinkels, L. J. A. C., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001133 · Cited by 24

An overview of immune checkpoint therapy in autoimmune diseases

Mohammadi, P., Hesari, M., Chalabi, M., Salari, F., & Khademi, F. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108647 · Cited by 28

Intratumoral antigen signaling traps CD8 + T cells to confine exhaustion to the tumor site

Takahashi, M., So, T. Y., Chamberlain-Evans, V., Hughes, R., Yam‐Puc, J. C., Kania, K., Ruhle, M., Mann, T., Schuijs, M. J., Coupland, P. G., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.ade2094 · Cited by 23

The Complex Dysregulations of CD4 T Cell Subtypes in HIV Infection

Tolomeo, M., & Cascio, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147512 · Cited by 28

Gene Map of the HLA Region, Graves’ Disease and Hashimoto Thyroiditis, and Hematopoietic Stem Cell Transplantation

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Cblb -deficient T cells are less susceptible to PD-L1-mediated inhibition

Peer, S., Baier, G., & Gruber, T. (2017) · Oncotarget · doi:10.18632/oncotarget.18360 · Cited by 26

Adhesive Interactions Delineate the Topography of the Immune Synapse

Martin-Cofreces, N. B., Vicente‐Manzanares, M., & Sánchez‐Madrid, F. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00149 · Cited by 24

The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma

Liao, P., Wang, H., Tang, Y., Tang, Y.-J., & Liang, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02457 · Cited by 27

Immune Checkpoint Inhibitors: Review of the Existing Evidence and Challenges in Breast Cancer

Jalalvand, M., Darbeheshti, F., & Rezaei, N. (2021) · Immunotherapy · doi:10.2217/imt-2020-0283 · Cited by 26

Reprogrammed CD4+ T Cells That Express FoxP3+ Control Inhibitory Antibody Formation in Hemophilia A Mice

Herzog, R. W., Kuteyeva, V., Saboungi, R., Terhorst, C., & Biswas, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00274 · Cited by 24

Imaging of Cancer Immunotherapy: Response Assessment Methods, Atypical Response Patterns, and Immune-Related Adverse Events, From the AJR Special Series on Imaging of Inflammation

Sheikhbahaei, S., Marcus, C. V., Sadaghiani, M. S., Rowe, S. P., Pomper, M. G., & Solnes, L. B. (2021) · American Journal of Roentgenology · doi:10.2214/ajr.21.26538 · Cited by 24

An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy

Jamison, B. L., Lawrance, M. F., Wang, C. J., DeBerg, H. A., Ziegler, L., Sansom, D. M., Gavin, M. A., Walker, L. S. K., & Campbell, D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114938 · Cited by 24

Inflammatory bowel disease and cancer response due to anti-CTLA-4: is it in the flora?

Carbonnel, F., Soularue, É., Coutzac, C., Chaput, N., Mateus, C., Lepage, P., & Robert, C. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-016-0613-x · Cited by 26

Tipping the balance: inhibitory checkpoints in intestinal homeostasis

Joosse, M. E., Nederlof, I., Walker, L. S. K., & Samsom, J. N. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0113-5 · Cited by 24

The suppressive effect of co-inhibiting PD-1 and CTLA-4 expression on H22 hepatomas in mice

Liang, L., Ge, K., Zhang, F., & Ge, Y. (2018) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-018-0122-0 · Cited by 24

Understanding and Overcoming the Inflammatory Toxicities of Immunotherapy

Dougan, M. L. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0372 · Cited by 24

CTLA-4-mediated trans-endocytosis in the control of T cell co-stimulation

Ovcinnikovs, V. (2018) · UCL Discovery (University College London)

Investigating transendocytosis mediated by CTLA4

Nguyen, L. (2023) · UNSWorks (University of New South Wales, Sydney, Australia) · doi:10.26190/unsworks/24962

CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis

Xu, X., Dennett, P., Zhang, J., Sherrard, A., Zhao, Y., Masubuchi, T., Bui, J. D., Chen, X., & Hui, E. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221391 · Cited by 56

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

Kennedy, A., Waters, E., Rowshanravan, B., Hinze, C., Williams, C., Janman, D., Fox, T. A., Booth, C., Pesenacker, A. M., Halliday, N., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01289-w · Cited by 227

Molecular and Cellular Functions of CTLA-4

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