Visualizing Long-Term Memory Formation in Two Neurons of the Drosophila Brain
Abstract
Challenging the Mushroom Bodies: Early memory is labile and is gradually consolidated over time into long-lasting, stable memory. In several species, including mammals, memory consolidation depends on protein synthesis. In Drosophila , long-term memory is produced by spaced repetitive training, which induces cyclic adenosine monophosphate (cAMP)–response element–binding protein (CREB)–dependent gene transcription and de novo protein synthesis. Using a large number of genetic tools, Chen et al. (p. 678 ; see the Perspective by Dubnau ) localized this CREB-dependent induction of de novo protein synthesis to two dorsal-anterior-lateral neurons in the adult brain. Importantly, protein synthesis was not required within the mushroom bodies, which are usually considered to be the site of associative learning and memory in insects.
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Even for systems such as honeybee olfactory learning that involve short, spaced intervals, effective long-term memory formation relies on activation of transcription and translation, downstream of the intracellular signalling pathways activated by these intervals.
“However, it is evident that even for systems such as honeybee olfactory learning that involve short, spaced intervals, effective long-term memory formation relies on the activation of transcription and translation, downstream of the intracellular signalling pathways that are activated by these intervals17,70.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [70]
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References 44 · Cited by 171
- Authors
- Chen, C.-C., Wu, J.-K., Lin, H.-W., Pai, T.-P., Fu, T.-F., Wu, C.-L., Tully, T., & Chiang, A.-S.
- Affiliations
- National Tsing Hua University (TW)
- National Chi Nan University (TW)
- Dart NeuroScience (United States) (US)
- Corresponding author
- Chiang, Ann-Shyn
- Venue
- Science
- Published
- 2012-02-10
- Volume
- 335
- Issue
- 6069
- Pages
- 678-685
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073858450
- Cited by
- 171
- References
- 44
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 13 · 2023: 7 · 2022: 8 · 2021: 14 · 2020: 4 · 2019: 6 · 2018: 12 · 2017: 9 · 2016: 8 · 2015: 14 · 2014: 18 · 2013: 25 · 2012: 16
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- long-term memory, Drosophila, mushroom body, protein synthesis, CREB, calcium/calmodulin-dependent protein kinase II, period gene, memory consolidation, memory retrieval, memory storage, memory circuits
- MeSH terms
- Animals, Axons, Brain, Conditioning, Psychological, Drosophila, Gene Expression Regulation, Luminescent Proteins, Neurons, Odorants, Sensory Receptor Cells, Ricin, Serine Endopeptidases, Transcriptional Activation, Trans-Activators, Genes, Insect, Cyclic AMP Response Element-Binding Protein, Gene Expression Profiling, Mushroom Bodies, Drosophila Proteins, Animals, Genetically Modified, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Cryptochromes, Period Circadian Proteins, Memory, Long-Term
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