Sexual Deprivation Increases Ethanol Intake in Drosophila
Open accessAbstract
Toward Addiction: Addiction can result when substances, such as drugs or alcohol, co-opt the brain's natural reward system. Shohat-Ophir et al. (p. 1351 ; see the Perspective by Zars ) explored this potential in Drosophila by examining the relationship between the natural reward stimulated by mating and the unnatural reward offered by ethanol consumption. Males deprived of mating increased consumption of ethanol, and, when permitted to mate following deprivation, their ethanol consumption decreased. At a mechanistic level, mating increased the neurotransmitter neuropeptide F (NPF), while mate deprivation decreased NPF levels.
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A wide variety of animal models show that sociality lowers self-administration of drugs such as cocaine, ethanol and opiates, and fruit flies prefer healthy foods over alcohol after social sexual interactions.
“A wide variety of animal models have been studied to show that sociality lowers self-administration of drugs such as cocaine, ethanol and opiates [73], and even fruit flies have been found to prefer healthy foods over alcohol after social sexual interactions [74].”
From The social origins of consciousness (2025) · cites this paper as [74]
Citation [74] applies to the fruit-fly clause, not the preceding claim about cocaine, ethanol and opiates in other animal models. In the passage describing the two-choice assay (section labeled Abstract; page unavailable), mated males had lower ethanol preference than sexually deprived males. The copy does not establish that mated flies preferred ethanol-free food over ethanol-containing food, or characterize either food as healthy. (LLM, conf=0.86)
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References 33 · Cited by 211
- Authors
- Shohat-Ophir, G., Kaun, K. R., Azanchi, R., Mohammed, H., & Heberlein, U.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Shohat-Ophir, G.
- Kaun, K. R.
- Azanchi, R.
- Heberlein, U.
- Venue
- Science
- Published
- 2012-03-16
- Volume
- 335
- Issue
- 6074
- Pages
- 1351-1355
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3909676
- OpenAlex
- W2033745381
- Cited by
- 211
- References
- 33
- Citations by year
- 2026: 12 · 2025: 20 · 2024: 12 · 2023: 10 · 2022: 17 · 2021: 20 · 2020: 12 · 2019: 10 · 2018: 20 · 2017: 8 · 2016: 15 · 2015: 13 · 2014: 12 · 2013: 14 · 2012: 16
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA010035)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- sexual deprivation, ethanol consumption, neuropeptide F, reward systems, mating behavior, ethanol preference, drug addiction, Drosophila melanogaster, neuronal activation
- MeSH terms
- TRPA1 Cation Channel, Acetates, Alcohol Drinking, Ethanol, Animals, Behavior, Animal, Conditioning, Psychological, Cues, Drosophila melanogaster, Female, Ion Channels, Male, Neurons, Neuropeptides, Oleic Acids, Pheromones, Reward, Sexual Behavior, Animal, Cohort Studies, Behavior, Addictive, Receptors, Neuropeptide, Drosophila Proteins, TRPC Cation Channels
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