Asymmetry and Aging of Mycobacterial Cells Lead to Variable Growth and Antibiotic Susceptibility

Aldridge, Bree B., Fernandez-Suarez, Marta, Heller, Danielle, Ambravaneswaran, Vijay, Irimia, Daniel, Toner, Mehmet, Fortune, Sarah M.·2012·Science

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  16. A state-structured pharmacodynamic framework separating resistance, tolerance and persistence, applied to Mycobacterium tuberculosis and Staphylococcus aureus
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  17. The Biofilm Microenvironment: Structure and Function
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  18. Role of Transcription Factor NR1H3 in the Pathogenesis of Tuberculosis
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  19. Increased proportion of growth-arrested bacilli in acidic pH adaptation promotes Mycobacterium tuberculosis treatment survival
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  23. Additional file 2 of Localization of EccA3 at the growing pole in Mycobacterium smegmatis
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  24. A Division-Associated Envelope Protein, MAB_2363, Drives Intrinsic Resistance and Virulence in Mycobacterium abscessus
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  25. MSMEG_1353 is a critical determinant of metabolic and cell envelope homeostasis in mycobacteria
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  26. Le système multiprotéique ORP spécifique de l'anaérobiose : mécanisme de régulation et fonction chez Desulfovibrio vulgaris Hildenborough
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  27. Mechanistic insights into the role of SepF in early cell division
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  28. Etude des mécanismes de transport d'une famille de lipides d'enveloppe, les polyphléates de tréhalose, chez Mycobacterium smegmatis
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  30. Vie intraostéoblastique de Staphylococcus aureus : étude de la dynamique de réplication et des persisters
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  31. FtsK with a unique N-terminal extension is involved in coordinating the final steps of chromosome segregation with asymmetric division in mycobacterial cells
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  32. A new Persister Enrichment Model in Mycobacterium tuberculosis links multidrug persistence to drug sequencing and maltokinase-dependent carbon distribution
    Michael W. Shultis, Claire V. Mulholland, Jinhua Cui, M Chen, Samantha Johnson, Christopher R. Hiner, Michael Berney · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Growth arrest of Mycobacterium tuberculosis in acidic environments enhances their survival of antibiotic treatment
    Eun Seon Chung, William C. Johnson, Maliwan Kamkaew, Timothy A. Fitzgerald, Morgan E. McNellis, Trever C. Smith, Srinivasan Vijay, Nguyễn Thụy Thương Thương, Shumin Tan, Bree B. Aldridge · 2026 · PLoS Biology
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  36. Reviewer #2 (Public review): Cell cycle dependent variation in endocytosis drives phenotypic diversity in M. tuberculosis
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  38. Reviewer #1 (Public review): Cell cycle dependent variation in endocytosis drives phenotypic diversity in M. tuberculosis
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  39. The polar landscape of bacterial pathogens and predators
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  40. Polar growth factor PgfA regulates polar peptidoglycan synthesis as well as mycolate synthesis in Mycobacterium smegmatis
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  41. Uncoupling mycomembrane biogenesis from mycolic acid synthesis reveals a distinct role for mycoloyltransferases in mycobacterial cell division
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  42. Multipronged Cell Wall-Targeting Converts Ineffective Antibiotics into a Potent Regimen against Mycobacterium abscessus
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  43. Division: An eternal rhythm of cells
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  44. Visualizing zinc-starved slow-replicating Mycobacterium tuberculosis in neutrophil-rich lung lesions
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  45. An adenylyl cyclase switch reroutes carbon from growth to virulence lipids in Mycobacterium tuberculosis
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  46. Metabolic flexibility and an unusual route for peptidoglycan muramic acid recycling in mycobacteria
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  48. BindingDB Entry 50042427: Identification of novel antimycobacterial chemical agents through the in silico multi-conformational structure-based drug screening of a large-scale chemical library.
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