Chitin-Induced Dimerization Activates a Plant Immune Receptor
Abstract
Dissecting Chitin Binding: The chitin in fungal cells walls serves as a trigger to initiate plant defenses against pathogenic fungi. Arabidopsis detects these signals through a cell surface chitin receptor whose intracellular kinase domain initiates a signaling cascade in response to chitin that activates the plant's response to infection. Liu et al. (p. 1160 ) have now solved the crystal structure of the Arabidopsis chitin receptor AtCERK1. The results show how chitin binds to the receptor and suggest that the biological response requires dimerisation of the receptor when it binds a chitin oligomer at least seven or eight subunits long.
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- Authors
- Liu, T., Liu, Z., Song, C., Hu, Y., Han, Z., She, J., Fan, F., Wang, J., Jin, C., Chang, J., Zhou, J.-M., & Chai, J.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Institute of Biological Sciences, Beijing (CN)
- Zhengzhou University (CN)
- Peking University (CN)
- Center for Life Sciences (CN)
- Tsinghua University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Liu, Tingting
- Liu, Zixu
- Chang, Junbiao
- Zhou, Jian-Min
- Chai, Jijie
- ORCID
- Venue
- Science
- Published
- 2012-06
- Volume
- 336
- Issue
- 6085
- Pages
- 1160-1164
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2113122247
- Cited by
- 680
- References
- 0
- Citations by year
- 2026: 33 · 2025: 43 · 2024: 51 · 2023: 50 · 2022: 61 · 2021: 45 · 2020: 57 · 2019: 41 · 2018: 45 · 2017: 54 · 2016: 47 · 2015: 43 · 2014: 51 · 2013: 40 · 2012: 19
- FWCI
- 55.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Studies on Chitinases and Chitosanases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- CERK1, receptor dimerization, chitin recognition, pattern recognition receptors, plant immunity, bivalent ligands, chitin oligomers, receptor activation, Arabidopsis thaliana, crystal structure
- MeSH terms
- Acetylglucosamine, Amino Acid Sequence, Binding Sites, Chitin, Hydrogen Bonding, Ligands, Models, Molecular, Molecular Sequence Data, Phosphorylation, Signal Transduction, Protein Serine-Threonine Kinases, Arabidopsis, Protein Structure, Tertiary, Crystallography, X-Ray, Amino Acid Motifs, Arabidopsis Proteins, Plants, Genetically Modified, Mutant Proteins, Receptors, Pattern Recognition, Protein Multimerization
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