The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Differential Diffusivity of Nodal and Lefty Underlies a Reaction-Diffusion Patterning System
Open accessAbstract
Reaction-Diffusion Patterning: Six decades ago, Alan Turing proposed the reaction-diffusion model to explain how complex patterns emerge during morphogenesis. In this model, an activator activates both itself and an inhibitor (the “reaction”), with the activator being less mobile than the inhibitor (“diffusion”). Many activator/inhibitor pairs have been described, but the role of differential mobility versus differential clearance of activators and inhibitors is often unclear. Now, Müller et al. (p. 721 , published online 12 April) show that during zebrafish embryogenesis, the activator Nodal has lower diffusivity than the inhibitor Lefty, while both molecules are cleared at similar rates, which supports the idea that Nodal and Lefty form a classical reaction-diffusion system.
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
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The chemical basis of morphogenesis
Turing, A. M. (1952) · Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences · doi:10.1098/rstb.1952.0012 · Cited by 11,733
Reaction-Diffusion Model as a Framework for Understanding Biological Pattern Formation
Kondo, S., & Miura, T. (2010) · Science · doi:10.1126/science.1179047 · Cited by 1,651
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Pigment Pattern Formation by Contact-Dependent Depolarization
Inaba, M., Yamanaka, H., & Kondo, S. (2012) · Science · doi:10.1126/science.1212821 · Cited by 172
Cited by
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Marcon, L., & Sharpe, J. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.11.013 · Cited by 130
Agent-based modeling of morphogenetic systems: advantages and challenges.
Glen, C. M., Kemp, M. L., & Voit, E. O. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006577 · Cited by 116
Cilia, calcium and the basis of left-right asymmetry
Norris, D. P. (2012) · BMC Biology · doi:10.1186/1741-7007-10-102 · Cited by 73
Cytoneme-mediated cell-to-cell signaling during development
Gradilla, A.-C., & Guerrero, I. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1578-x · Cited by 52
Quantitative diffusion measurements using the open-source software PyFRAP
Bläßle, A., Soh, G., Braun, T., Mörsdorf, D., Preiß, H., Jordan, B. M., & Müller, P. (2018) · Nature Communications · doi:10.1038/s41467-018-03975-6 · Cited by 49
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Metadata
- Authors
- Müller, P., Rogers, K. W., Jordan, B. M., Lee, J. S., Robson, D., Ramanathan, S., & Schier, A. F.
- Venue
- Science
- Published
- 2012-05-11
- Volume
- 336
- Issue
- 6082
- Pages
- 721-724
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2127071442
- Cited by
- 381
- References
- 5
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- green
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