The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2
Open accessAbstract
Distinguishing Right from Left: In most vertebrates during embryonic development, rotational movement of the cilia within a structure in the embryo, known as the node, generates unidirectional flow required for future left-right asymmetry of the internal organs. The flow may transport a determinant molecule or provide mechanical force. However, it is not clear how the flow is sensed. Yoshiba et al. (p. 226 , published online 13 September; see the Perspective by Norris and Grimes ) show that nodal flow in mouse embryos is sensed by the cilia of perinodal cells located at the edge of the node, in a manner dependent on Pkd2, a Ca 2+ -permeable cation channel that has been implicated in polycystic kidney disease in humans.
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Cites
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
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Self-citationTwo Populations of Node Monocilia Initiate Left-Right Asymmetry in the Mouse
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Polycystin-2 is an intracellular calcium release channel
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Self-citationRelationship between asymmetric nodal expression and the direction of embryonic turning
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Cited by
Pierpont, M. E., Brueckner, M., Chung, W. K., Garg, V., Lacro, R. V., McGuire, A. L., Mital, S., Priest, J. R., Pu, W. T., Roberts, A., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000606 · Cited by 654
Endothelial Cilia Mediate Low Flow Sensing during Zebrafish Vascular Development
Goetz, J. G., Steed, E., Ferreira, R. R., Roth, S., Ramspacher, C., Boselli, F., Charvin, G., Liebling, M., Wyart, C., Schwab, Y., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.032 · Cited by 219
Primary cilium-dependent signaling mechanisms
Pala, R., Alomari, N., & Nauli, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112272 · Cited by 205
Advances in the Genetics of Primary Ciliary Dyskinesia
Horani, A., & Ferkol, T. W. (2018) · Chest · doi:10.1016/j.chest.2018.05.007 · Cited by 147
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways
Sigg, M. A., Menchen, T., Lee, C., Johnson, J., Jungnickel, M. K., Choksi, S. P., Garcia, G., Busengdal, H., Dougherty, G. W., Pennekamp, P., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.11.014 · Cited by 130
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Metadata
- Authors
- Yoshiba, S., Shiratori, H., Kuo, I. Y., Kawasumi, A., Shinohara, K., Nonaka, S., Asai, Y., Sasaki, G., Belo, J. A., Sasaki, H., Nakai, J., Dworniczak, B., Ehrlich, B. E., Pennekamp, P., & Hamada, H.
- Venue
- Science
- Published
- 2012-10-12
- Volume
- 338
- Issue
- 6104
- Pages
- 226-231
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966411806
- Cited by
- 306
- References
- 26
- FWCI
- 17.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Yoshiba, S., Shiratori, H., Kuo, I. Y., Kawasumi, A., Shinohara, K., Nonaka, S., Asai, Y., Sasaki, G., Belo, J. A., Sasaki, H., Nakai, J., Dworniczak, B., Ehrlich, B. E., Pennekamp, P., & Hamada, H. (2012). Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2. Science. https://doi.org/10.1126/science.1222538
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