Depression and Hippocampal Neurogenesis: A Road to Remission?
Open accessAbstract
Adult-generated hippocampal neurons are required for mood control and antidepressant efficacy, raising hopes that someday we can harness the power of new neurons to treat mood disorders such as depression. However, conflicting findings from preclinical research—involving stress, depression, and neurogenesis—highlight the complexity of considering neurogenesis as a road to remission from depression. To reconcile differences in the literature, we introduce the “neurogenic interactome,” a platform from which to consider the diverse and dynamic factors regulating neurogenesis. We propose consideration of the varying perspectives—system, region, and local regulation of neurogenesis—offered by the interactome and exchange of ideas between the fields of learning and memory and mood disorder research to clarify the role of neurogenesis in the etiology and treatment of depression.
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Various models of chronic stress exposure in rodents decrease neurogenesis in the dentate gyrus of the hippocampus, involving reduced proliferation, survival, and differentiation of neural stem cells.
“In addition, various models of chronic stress exposure in rodents have indicated a decrease in neurogenesis in the dentate gyrus (DG) of the hippocampus, involving a reduced proliferation, survival, and differentiation of neural stem cells (Eisch and Petrik 2012).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Eisch and Petrik 2012
The indexed passage labeled Abstract (page not supplied) says that strong or unpredictable stress decreases adult neurogenesis. It also cautions that stress does not always decrease neurogenesis. The copy does not substantiate the claimed reductions in neural stem-cell proliferation, survival, and differentiation across various chronic-stress models. (LLM, conf=0.87)
Experimental — accuracy not yet measuredNeuroinflammation can induce dysregulation of the HPA axis and decrease serotonin levels, as well as alter the hippocampus, mechanisms involved in major depressive disorder.
“It has been reported that neuroinflammation can induce the dysregulation of the hypothalamus–pituitary–adrenal (HPA) axis [83] and decrease serotonin levels [84], as well as altering the hippocampus [85], mechanisms involved in major depressive disorder (MDD) [81].”
From Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood (2023) · cites this paper as [85]
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References 26 · Cited by 516
- Authors
- Eisch, A. J., & Petrik, D.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390–9070, USA.
- Corresponding author
- Eisch, Amelia J.
- ORCID
- Eisch, Amelia J.
- Venue
- Science
- Published
- 2012-10-05
- Volume
- 338
- Issue
- 6103
- Pages
- 72-75
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3756889
- OpenAlex
- W2088135834
- Cited by
- 516
- References
- 26
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 32 · 2023: 22 · 2022: 38 · 2021: 42 · 2020: 32 · 2019: 42 · 2018: 32 · 2017: 34 · 2016: 37 · 2015: 55 · 2014: 55 · 2013: 43 · 2012: 2
- FWCI
- 16.71
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- National Institute on Drug Abuse (K02DA023555, R01DA016765)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- depression, hippocampal neurogenesis, adult neurogenesis, antidepressant efficacy, mood disorders, stress, neurogenesis regulation, learning and memory, depression remission
- MeSH terms
- Animals, Depressive Disorder, Major, Major Depressive Disorder, Hippocampus, Humans, Learning, Memory, Mice, Transgenic, Neurons, Mice, Neurogenesis
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