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Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures
Open accessAbstract
Channels from DNA: Artificial transmembrane channels are of interest for applications, such as sensing and modifying cell signaling. Langecker et al. (p. 932 ; see the Perspective by Strano ) used α-hemolysin as a model for creating a nanostructure with DNA origami that, when inserted into a lipid bilayer membrane, acted as a membrane channel. Ion channel responses were similar to those measured for natural ion channels, and channels that protruded further into the membrane exhibited greater gating responses. The channels were used to detect single-DNA molecules.
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Citations
Cited by
Seeman, N. C., & Sleiman, H. F. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.68 · Cited by 1,875
Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts
Stewart, M. P., Langer, R., & Jensen, K. F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00678 · Cited by 747
Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy
Meng, H.-M., Liu, H., Kuai, H., Peng, R., Mo, L., & Zhang, X.-B. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00645g · Cited by 608
DNA nanotechnology from the test tube to the cell
Chen, Y.-J., Groves, B., Muscat, R. A., & Seelig, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.195 · Cited by 594
Virus-Inspired Membrane Encapsulation of DNA Nanostructures To Achieve In Vivo Stability
Perrault, S. D., & Shih, W. M. (2014) · ACS Nano · doi:10.1021/nn5011914 · Cited by 522
Metadata
- Authors
- Langecker, M., Arnaut, V., Martin, T. G., List, J., Renner, S., Mayer, M., Dietz, H., & Simmel, F. C.
- Venue
- Science
- Published
- 2012-11-16
- Volume
- 338
- Issue
- 6109
- Pages
- 932-936
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2062882464
- Cited by
- 758
- References
- 0
- FWCI
- 29.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Langecker, M., Arnaut, V., Martin, T. G., List, J., Renner, S., Mayer, M., Dietz, H., & Simmel, F. C. (2012). Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures. Science. https://doi.org/10.1126/science.1225624
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