Regulatory T Cells Increase the Avidity of Primary CD8 + T Cell Responses and Promote Memory
Open accessAbstract
Treg-ulating Immune Responses: There are many checks and balances to keep the immune system from running amok. One of the most critical is a specialized population of T cells, called regulatory T cells (T regs ). In their absence, a lethal autoimmune disease develops in both humans and mice. Although T regs are well known for their suppression of autoimmune responses, how they modulate responses to infectious agents is less well understood. Using inducible deletion of T regs in mice, Pace et al. (p. 532 ) showed that T regs are important for shaping the avidity of CD8 + T cell responses. In the absence of T regs , CD8 + T cell responses were of lower avidity, and the CD8 + T cells were more responsive to lower-affinity antigens. When T regs were absent, stable interactions between T cell and antigen-presenting cells were increased as a result of higher amounts of chemokine expression in the lymph nodes. T reg depletion also resulted in a lower-avidity CD8 + T cell response to infection with the bacterial pathogen Listeria monocytogenes .
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The neutralizing antibodies for CCL2 and CCL3/4/5 have been shown to be effective in neutralizing the corresponding chemokines in published experiments.
“These antibodies have been shown to be effective in neutralizing the corresponding chemokines in published experiments (Martinez de la Torre et al., 2007; Pace et al., 2012).”
From p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells (2013) · cites this paper as Pace et al., 2012
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References 35 · Cited by 152
Research works printed but not linked: 4
- M. M. Davis, J. D. Altman, E. W. Newell, Nat Rev Immunol 11, 551 (2011).
- V. Dal Secco et al., PLoS One 4, e7696 (2009).
- C. Kervrann, J. Boulanger, IEEE Trans Image Process 15, 2866 (Oct, 2006).
- J. Boulanger et al., IEEE Trans Med Imaging 29, 442 (Feb, 2009).
- Authors
- Pace, L., Tempez, A., Arnold-Schrauf, C., Lemaitre, F., Bousso, P., Fetler, L., Sparwasser, T., & Amigorena, S.
- Affiliations
- Inserm (FR)
- Institute of Infection Immunology, Centre for Experimental and Clinical Infection Research, TWINCORE, D-30625 Hannover, Germany.
- INSERM U668, Department of Immunology, Institut Pasteur, F-75015 Paris, France.
- Centre National de la Recherche Scientifique (FR)
- Center for Experimental and Clinical Infection Research (DE)
- INSERM U932, Immunity and Cancer, Institut Curie, F-75248 Paris Cedex 05, France.
- Corresponding author
- Tempez, Andy
- Fetler, Luc
- Sparwasser, Tim
- Venue
- Science
- Published
- 2012-10-26
- Volume
- 338
- Issue
- 6106
- Pages
- 532-536
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072116490
- Cited by
- 152
- References
- 35
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 13 · 2022: 11 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 14 · 2015: 16 · 2014: 19 · 2013: 15 · 2012: 2
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- HZI (Helmholtz Centre for Infection Research) (submittedVersion)
- Funders
- Boehringer Ingelheim Fonds
- Institut National de la Santé et de la Recherche Médicale
- Ligue Contre le Cancer
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- regulatory T cells, CD8+ T cell responses, T cell receptor avidity, Treg depletion, Listeria monocytogenes infection, chemokine expression, antigen-presenting cells, T cell memory, immune tolerance
- MeSH terms
- Animals, Female, Immunity, Cellular, Immunologic Memory, Listeriosis, Listeria monocytogenes, Lymphocyte Depletion, Mice, Inbred C57BL, Proteins, Minor Histocompatibility Antigens, CD8-Positive T-Lymphocytes, Chemokine CCL5, T-Lymphocytes, Regulatory, Mice, Chemokine CCL1, Chemokine CCL4
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