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Crystal Structure of the Calcium Release–Activated Calcium Channel Orai
Open accessAbstract
Architecture of a CRAC: The calcium release–activated calcium (CRAC) channel generates intracellular calcium signals in response to depletion of calcium from the endoplasmic reticulum. Hou et al. (p. 1308 , published online 22 November) report a high-resolution crystal structure of Orai, the CRAC channel pore from Drosophila melanogaster. Six Orai subunits surround a central pore that extends into the cytosol. The pore is in a closed conformation that is stabilized by anions binding to a basic region near the intracellular side. A ring of glutamates on the extracellular side form a selectivity filter. The channel architecture allows calcium permeation while regulating the flow to prevent overloading the cell with calcium.
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Metadata
- Authors
- Hou, X., Pedi, L., Diver, M. M., & Long, S. B.
- Venue
- Science
- Published
- 2012-12-07
- Volume
- 338
- Issue
- 6112
- Pages
- 1308-1313
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1967218656
- Cited by
- 564
- References
- 2
- FWCI
- 16.73
- Type
- journal article
- Language
- en
- Open access
- green
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