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EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues
Open accessAbstract
Translating Polyproline: Translation of messenger RNA into protein is carried out by the ribosome, together with a variety of accessory factors, which offer the potential for regulation of this critical step in gene expression (see the Perspective by Buskirk and Green ). Ude et al. (p. 82 , published online 13 December), using bacterial genetics and an in vitro reconstituted translation system, and Doerfel et al. (p. 85 , published online 13 December), using a model assay for peptide bond formation, find that the universally conserved bacterial elongation factor P (EF-P) (which is orthologous to the archaeal and eukaryotic initiation factor 5A) is required for the efficient translation of polyproline-containing polypeptides. Such short polyproline stretches (with runs of two, three, or more proline residues) would otherwise cause ribosomal stalling.
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Citations
Cited by
eIF5A Promotes Translation of Polyproline Motifs
Gutierrez, E., Shin, B.-S., Woolstenhulme, C. J., Kim, J.-R., Saini, P., Buskirk, A. R., & Dever, T. E. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.04.021 · Cited by 522
Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations
Buhr, F., Jha, S., Thommen, M., Mittelstaet, J., Kutz, F., Schwalbe, H., Rodnina, M. V., & Komar, A. A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.008 · Cited by 395
Self-citationPolyamines control eIF5A hypusination, TFEB translation, and autophagy to reverse B cell senescence
Zhang, H., Alsaleh, G., Feltham, J., Sun, Y., Napolitano, G., Riffelmacher, T., Charles, P., Frau, L., Hublitz, P., Yu, Z., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.08.005 · Cited by 341
The bacterial translation stress response.
Starosta, A. L., Lassak, J., Jung, K., & Wilson, D. N. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12083 · Cited by 210
Sequence selectivity of macrolide-induced translational attenuation
Davis, A. R., Gohara, D. W., & Yap, M.-N. F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410356111 · Cited by 123
Metadata
- Authors
- Doerfel, L. K., Wohlgemuth, I., Kothe, C., Peske, F., Urlaub, H., & Rodnina, M. V.
- Venue
- Science
- Published
- 2013-01-04
- Volume
- 339
- Issue
- 6115
- Pages
- 85-88
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2158527336
- Cited by
- 489
- References
- 0
- FWCI
- 13.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Doerfel, L. K., Wohlgemuth, I., Kothe, C., Peske, F., Urlaub, H., & Rodnina, M. V. (2013). EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues. Science. https://doi.org/10.1126/science.1229017
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