The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing
Open accessAbstract
Single-Cell Sequencing: With the rapid progress in sequencing technologies, single-cell sequencing is now possible, promising insight into how cell-to-cell heterogeneity affects biological behavior. Achieving adequate genome coverage remains a challenge because single-cell sequencing relies on genome amplification that is prone to sequence bias. Zong et al. (p. 1622 ) report a new amplification method: multiple annealing and looping-based amplification cycles that allowed 93% genome coverage for a human cell. This coverage facilitated accurate detection of point mutations and copy number variations. Lu et al. (p. 1627 ) used the method to sequence 99 sperm cells from a single individual. Mapping the meiotic crossovers revealed a nonrandom distribution with a reduced recombination rate near transcription start sites.
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Cites
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Self-citationA Fine-Scale Map of Recombination Rates and Hotspots Across the Human Genome
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Cited by
Single-cell genome sequencing: current state of the science
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Single-cell sequencing-based technologies will revolutionize whole-organism science
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Self-citationTumour heterogeneity and metastasis at single-cell resolution
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Metadata
- Authors
- Lu, S., Zong, C., Fan, W., Yang, M., Li, J., Chapman, A. R., Zhu, P., Hu, X., Xu, L., Yan, L., Bai, F., Qiao, J., Tang, F., Li, R., & Xie, X. S.
- Venue
- Science
- Published
- 2012-12-21
- Volume
- 338
- Issue
- 6114
- Pages
- 1627-1630
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979025775
- Cited by
- 297
- References
- 34
- FWCI
- 25.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Lu, S., Zong, C., Fan, W., Yang, M., Li, J., Chapman, A. R., Zhu, P., Hu, X., Xu, L., Yan, L., Bai, F., Qiao, J., Tang, F., Li, R., & Xie, X. S. (2012). Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing. Science. https://doi.org/10.1126/science.1229112
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