The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
A Strategy for Modulation of Enzymes in the Ubiquitin System
Open accessAbstract
Modifying Deubiquitinases: Protein ubiquitination is a widespread mechanism for cellular regulation, and new regulators are valuable research tools and may help to generate therapeutic small molecules. Ernst et al. (p. 590 , published online 3 January) used known crystal structures to roughly define the interaction domain between a ubiquitin-specific protease and a ubiquitinated substrate and then screened ubiquitin variants with changes in these residues to find variants that acted as potent and specific regulators that could modify ubiquitin pathway regulation in cells.
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Self-citationTSC1 Stabilizes TSC2 by Inhibiting the Interaction between TSC2 and the HERC1 Ubiquitin Ligase
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Drugging the undruggables: exploring the ubiquitin system for drug development
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System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes
Zhang, W., Wu, K.-P., Sartori, M. A., Kamadurai, H. B., Ordureau, A., Jiang, C., Mercredi, P. Y., Murchie, R., Hu, J., Persaud, A., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.02.005 · Cited by 168
Self-citationThe deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling
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Machine learning modeling of family wide enzyme-substrate specificity screens
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Metadata
- Authors
- Ernst, A., Avvakumov, G., Tong, J., Fan, Y., Zhao, Y., Alberts, P., Persaud, A., Walker, J. R., Neculai, A.-M., Neculai, D., Vorobyov, A., Garg, P., Beatty, L., Chan, P.-K., Juang, Y.-C., Landry, M.-C., Yeh, C., Zeqiraj, E., Karamboulas, K., Allali-Hassani, A., Vedadi, M., Tyers, M., Moffat, J., Sicheri, F., Pelletier, L., Durocher, D., Raught, B., Rotin, D., Yang, J., Moran, M. F., Dhe-Paganon, S., & Sidhu, S. S.
- Venue
- Science
- Published
- 2013-02
- Volume
- 339
- Issue
- 6119
- Pages
- 590-595
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974389826
- Cited by
- 283
- References
- 10
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Ernst, A., Avvakumov, G., Tong, J., Fan, Y., Zhao, Y., Alberts, P., Persaud, A., Walker, J. R., Neculai, A.-M., Neculai, D., Vorobyov, A., Garg, P., Beatty, L., Chan, P.-K., Juang, Y.-C., Landry, M.-C., Yeh, C., Zeqiraj, E., Karamboulas, K., . . . Sidhu, S. S. (2013). A Strategy for Modulation of Enzymes in the Ubiquitin System. Science. https://doi.org/10.1126/science.1230161
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
