Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation
Abstract
MicroRNA Mechanism: MicroRNAs are small noncoding RNAs that regulate gene expression by binding complementary target messenger RNAs (mRNAs) and repressing their expression through repression of protein translation and mRNA degradation. Meijer et al. (p. 82 ) show that in a HeLa cell system mRNA degradation is a consequence of translational inhibition via the initiation factor eIF4A2.
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The isoforms eIF4A1 and eIF4A2 have different functions.
“The isoforms eIF4A1 and eIF4A2 have been shown to have different functions (40).”
From Targeting eIF4A-dependent translation in genetically complex sarcoma (2026) · cites this paper as [40]
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References 38 · Cited by 326
- Authors
- Meijer, H. A., Kong, Y. W., Lu, W. T., Wilczynska, A., Spriggs, R. V., Robinson, S. W., Godfrey, J. D., Willis, A. E., & Bushell, M.
- Affiliations
- Medical Research Council (GB)
- Corresponding author
- Meijer, H. A.
- Kong, Y. W.
- Lu, W. T.
- Wilczynska, A.
- Bushell, M.
- Venue
- Science
- Published
- 2013-04-05
- Volume
- 340
- Issue
- 6128
- Pages
- 82-85
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067024190
- Cited by
- 326
- References
- 38
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 6 · 2023: 13 · 2022: 17 · 2021: 19 · 2020: 22 · 2019: 21 · 2018: 31 · 2017: 25 · 2016: 38 · 2015: 37 · 2014: 60 · 2013: 24
- FWCI
- 18.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- Medical Research Council (MC_EX_G0902052)
- Biotechnology and Biological Sciences Research Council (BB/B500915/1, BB/F019017/1, BB/F011806/2, BB/F019017/2, BB/F02326X/2, BB/F011806/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- microRNA, protein synthesis inhibition, EIF4A2, mRNA degradation, microRNA binding sites, 3' untranslated region, RNA helicase, post-transcriptional regulation
- MeSH terms
- Gene Expression Regulation, HeLa Cells, Humans, RNA, Messenger, Protein Biosynthesis, RNA Stability, MicroRNAs, Eukaryotic Initiation Factor-4A, HEK293 Cells
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