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Amplifying Genetic Logic Gates
Abstract
Biological Transistor: A transistor is a device that amplifies and switches electronic signals. Bonnet et al. (p. 599 , published online 28 March; see the Perspective by Benenson ) engineered a genetic circuit to behave like a transistor in individual living cells. Instead of regulating messenger RNA levels, which has been used previously in designing such systems, the approach relied on changing the state of double-stranded DNA. Six basic logic gates were designed and constructed that were based on the activity of two serine recombinases.
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Cited by
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Nielsen, A. A. K., Der, B. S., Shin, J., Vaidyanathan, P., Paralanov, V., Strychalski, E. A., Ross, D., Densmore, D., & Voigt, C. A. (2016) · Science · doi:10.1126/science.aac7341 · Cited by 1,020
A brief history of synthetic biology
Cameron, D. E., Bashor, C. J., & Collins, J. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3239 · Cited by 933
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Brophy, J. A. N., & Voigt, C. A. (2014) · Nature Methods · doi:10.1038/nmeth.2926 · Cited by 931
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Paddon, C. J., & Keasling, J. D. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3240 · Cited by 675
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Metadata
- Authors
- Bonnet, J., Yin, P., Ortiz, M. E., Subsoontorn, P., & Endy, D.
- Venue
- Science
- Published
- 2013-05-03
- Volume
- 340
- Issue
- 6132
- Pages
- 599-603
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2090876232
- Cited by
- 505
- References
- 0
- FWCI
- 24.61
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
