Drosophila H1 Regulates the Genetic Activity of Heterochromatin by Recruitment of Su(var)3-9
Open accessAbstract
Silencing Transposons: Eukaryotic DNA is packaged onto nucleosomes, which are composed of four core histones (H2A, H2B, H3, and H4). Chromatin also contains a fifth histone, H1, which binds to both the core particles and the “linker” DNA that joins adjacent nucleosomes, where it helps chromatin to fold into higher-order structures and generally silences gene expression. In Drosophila germline and somatic cells and tissues, Lu et al. (p. 78 ) found that the repressive function of H1 in vivo was directed toward transposable elements and independent of small RNA silencing pathways. Instead, H1 acted through direct recruitment of the histone methyltransferase Su(var)3–9, which methylates histone H3 lysine 9, a repressive histone mark.
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R1 and R2 elements exhibit an increased level of H1 linker histone.
“In addition, R1 and R2 elements exhibited an increased level of H1 linker histone (Figure 1C), which is also mainly associated with repressive chromatin in Drosophila (62,75,83).”
From Impaired function of rDNA transcription initiation machinery leads to derepression of ribosomal genes with insertions of R2 retrotransposon (2022) · cites this paper as [83]
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Fefelova, E. A., Pleshakova, I. M., Mikhaleva, E. A., Pirogov, S. A., Poltorachenko, V. A., Abramov, Y. A., Romashin, D. D., Shatskikh, A. S., Blokh, R. S., Gvozdev, V. A., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1276 · Cited by 15 · see citing works
“In addition, R1 and R2 elements exhibited an increased level of H1 linker histone (Figure 1C), which is also mainly associated with repressive chromatin in Drosophila (62,75,83).”
Background
- Authors
- Lu, X., Wontakal, S. N., Kavi, H., Kim, B. J., Guzzardo, P. M., Emelyanov, A. V., Xu, N., Hannon, G. J., Zavadil, J., Fyodorov, D. V., & Skoultchi, A. I.
- Affiliations
- Albert Einstein College of Medicine (US)
- Cold Spring Harbor Laboratory (US)
- Department of Pathology and NYU Center for Health Informatics and Bioinformatics, New York University Langone Medical Center, New York, NY 10016, USA.
- Corresponding author
- Fyodorov, Dmitry V.
- Skoultchi, Arthur I.
- Venue
- Science
- Published
- 2013-04-05
- Volume
- 340
- Issue
- 6128
- Pages
- 78-81
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3756538
- OpenAlex
- W2000392583
- Cited by
- 105
- References
- 0
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 2 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 15 · 2014: 9 · 2013: 6
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (2P30-CA13330, R56CA079057, CA079057, R01CA079057, P30CA013330)
- National Institute of General Medical Sciences (5 T32 GM0728, GM074233, GM093190, R01GM093190, R01GM074233, R37GM062534)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- histone H1, heterochromatin, Su(var)3-9, H3K9 methylation, transposon silencing, repetitive DNA, chromatin condensation, chromatin accessibility, Drosophila
- MeSH terms
- Animals, Drosophila melanogaster, Heterochromatin, Histones, Muscle Proteins, Repetitive Sequences, Nucleic Acid, Repressor Proteins, Transcription Factors, Gene Silencing, Drosophila Proteins, RNA Interference
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