Emerging principles for the therapeutic exploitation of glycosylation
Abstract
Glycosylation plays a key role in a wide range of biological processes. Specific modification to a glycan's structure can directly modulate its biological function. Glycans are not only essential to glycoprotein folding, cellular homeostasis, and immune regulation but are involved in multiple disease conditions. An increased molecular and structural understanding of the mechanistic role that glycans play in these pathological processes has driven the development of therapeutics and illuminated novel targets for drug design. This knowledge has enabled the treatment of metabolic disorders and the development of antivirals and shaped cancer and viral vaccine strategies. Furthermore, an understanding of glycosylation has led to the development of specific drug glycoforms, for example, monoclonal antibodies, with enhanced potency.
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The conserved Fc site Asn297 in IgG1 is N-glycosylated and essential to the anti- or proinflammatory role of IgGs.
“The conserved Fc site Asn297 in IgG1 is N-glycosylated, which is essential to the anti- or proinflammatory role of IgGs (Figure 1) [2].”
From Glycoengineering Chinese hamster ovary cells: a short history (2021) · cites this paper as [2]
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References 98 · Cited by 447
- Authors
- Dalziel, M., Crispin, M., Scanlan, C. N., Zitzmann, N., & Dwek, R. A.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Dalziel, Martin
- Crispin, Max
- Scanlan, Christopher N.
- Dwek, Raymond A.
- Venue
- Science
- Published
- 2014-01-03
- Volume
- 343
- Issue
- 6166
- Pages
- 1235681-1235681
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013180631
- Cited by
- 447
- References
- 98
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 21 · 2023: 24 · 2022: 31 · 2021: 32 · 2020: 40 · 2019: 36 · 2018: 34 · 2017: 48 · 2016: 61 · 2015: 55 · 2014: 34 · 2012: 1
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Funders
- Medical Research Council (MC_PC_12020)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Keywords
- glycosylation, glycans, glycoprotein folding, immune regulation, disease mechanisms, drug design, metabolic disorders, antiviral agents, cancer vaccines, viral vaccines, monoclonal antibodies
- MeSH terms
- Antibodies, Monoclonal, Antiviral Agents, Glycolipids, Glycoproteins, Glycosylation, Humans, Metabolic Diseases, Neoplasms, Polysaccharides, Viral Vaccines, Drug Design, HIV Infections, Cancer Vaccines
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